about
sameAs
SMAD3 ser-423 ser-425 phosphorylatedL-aspartic acid residue 258 replaced with L-asparagineL-arginine residue 268 replaced with L-cysteineL-aspartic acid residue 258 replaced with L-asparagine ser-423 ser-425 phosphorylatedL-arginine residue 268 replaced with L-cysteine ser-423 ser-425 phosphorylatedSMAD3 ser-423 ser-425 ser-179 phosphorylatedSMAD3 ser-423 ser-425 ser-50 ser-52 phosphorylatedSMAD3 ser-unknown phosphorylatedSMAD3 ser-423 ser-425 phosphorylated [nucleoplasm]
P279
P688
Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoterSmurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradationResponse gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cellsNodal and ALK7 inhibit proliferation and induce apoptosis in human trophoblast cellsThe MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoterAblation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signalingNuclear targeting of transforming growth factor-beta-activated Smad complexesFeatures of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA bindingHepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activationHepatitis C virus core variants isolated from liver tumor but not from adjacent non-tumor tissue interact with Smad3 and inhibit the TGF-beta pathwayRequirement of the co-repressor homeodomain-interacting protein kinase 2 for ski-mediated inhibition of bone morphogenetic protein-induced transcriptional activationSmad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcriptionLigand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signalingPin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteinsHeteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4Cellular response to hypoxia involves signaling via Smad proteinsHolding their own: the noncanonical roles of Smad proteinsTransforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transitionReceptor-associated Mad homologues synergize as effectors of the TGF-beta responseHMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transitionTGFbeta-Smad signalling in postoperative human lens epithelial cellsHEB and E2A function as SMAD/FOXH1 cofactorsIdentification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1Activin receptor-like kinase-7 induces apoptosis through activation of MAPKs in a Smad3-dependent mechanism in hepatoma cellsThe integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokinesPPM1A functions as a Smad phosphatase to terminate TGFbeta signalingUSP15 is a deubiquitylating enzyme for receptor-activated SMADsMicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial HypertensionMiRNA-199a-5p influences pulmonary artery hypertension via downregulating Smad3MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissueSyntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalizationIdentification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta actionSMAD proteins control DROSHA-mediated microRNA maturationThe novel PIAS-like protein hZimp10 enhances Smad transcriptional activity.Pin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
P921
Q50369589-6853152A-CB61-49F8-A602-4BFED1C60316Q50369832-B425C399-54F7-47DC-A2BD-9417F9BA4353Q50369833-88D3E17D-6448-484B-B695-46FF31BFDCD8Q50369839-1DD513DC-3445-43F2-BF30-70114E734C9DQ50369840-9DA47F40-802C-4C51-AA90-569B0D5336D2Q50371986-990FB7DC-27CA-477C-A22D-E73A044D5E19Q50371988-56AE6DA8-FC3F-456A-AF16-DEF9270B70E6Q50373601-1F0BD7AD-BC1D-4D88-856B-7DDB21315C83Q50677164-04A4E61D-25C4-4F89-8C8B-7449E5AD8182
P279
Q50255075-8C486515-D81C-45BE-B44E-F759721E01FFQ50255077-8DFC59C4-A9DF-4405-8461-12CB3BEAF788Q50255084-735B122A-A303-4459-839A-16C48415B702Q50256087-421189BF-4DB5-4620-8B82-3A5DD2AF6C0BQ50256092-094D9188-A650-49F3-826E-6BCFE346E092Q50257925-83024271-8047-40D4-947D-D656D4C5ACE1Q50257956-495E2611-3515-4B70-9EB2-FE9745B6CF83Q50257959-8CDB47D6-A4F0-462C-A17E-7F5A821B54A7Q50268880-D40B5635-CBEB-4A7C-927A-29EBD7A24961Q50272229-EB8DA069-BABA-48BA-8072-5CA0A00C5E82Q50272231-2BE6289F-580A-4E00-A3F3-CAAD511A65B3Q50298185-F2E0167D-663A-4220-BFFA-8735E3702169Q55182765-049B7010-0242-4FFE-87FB-CBEC8E8A7C7AQ55216288-05FABA36-E28F-45CD-AFE7-204E42FD9C27
P527
Q22254141-24429DFB-51A7-4295-8BAB-32CCC1854B30Q24291000-6C58F076-54B8-43F9-924A-E2CF94CF4FB4Q24292825-8FCDCABD-DF65-4B4B-9C67-1BD837B30B5FQ24293592-7DCBC557-2B98-4B0D-ADDE-018239E91C4EQ24294427-4F6A807B-4D56-4990-AAC9-417FEBF92FD1Q24295158-C63C706F-4603-4F72-AE82-2308533F0CCCQ24297637-1EB6D50A-C937-4858-9166-FDB1A3E5F1F9Q24298286-8242224E-EA47-45E4-B644-B1DA04B1A394Q24299213-11D539B9-C87C-489E-8976-0F4B0D8B6B66Q24299610-8FA2F5C7-6FA8-435A-BD66-E4DBDAB8A386Q24302050-E3404B97-A669-462F-923A-33ADB204BE51Q24307549-69C867E0-E902-4182-86BB-4379B5E6373EQ24310350-5E5AB273-667A-4179-BEE8-C5FDDDAF2F03Q24311810-79B72467-5733-497D-8E77-9645C610C8B9Q24313188-0B8814FB-F20B-4869-B2A9-7129F1E1D24DQ24313316-64CFE712-6A46-4ACB-AFF0-8FF2071D55F8Q24314569-2963F873-643B-45FA-80B7-4E7A1AE60563Q24314661-F35B5684-C1B3-4B9C-84D4-7D894D0093D6Q24314797-3A6CAF78-AC96-4D2B-9EC7-1EA6BDC161F2Q24316045-B6A1B460-E635-4480-AC33-E970E2E419C5Q24316645-23686B9C-D32A-4092-B880-9811EF134C1BQ24318330-46F0D2DB-1B0F-4A5B-9CB0-C272C08ECE2EQ24318681-616A84E4-2049-4097-91FB-500CAB178A0CQ24320125-DE37BE1F-B82F-4BBE-B182-64579E6C4B8AQ24320356-4255F60D-5B6D-4DA0-8B56-44E88B29C9BDQ24336739-BF5E0A94-497C-469C-94A8-6EF787373728Q24337844-7ACF2384-C1AB-45D4-ADCD-86FC6BFFDD21Q24337892-3FFFFF44-C94E-4355-B7B0-34126866C8B5Q24338559-56A87053-5918-4955-9E33-BD0E947C5AAFQ24338646-A775C344-95EE-4BCD-9422-8A1C63103123Q28114802-6AC1CAE6-74CA-46E3-B7CD-623D9CAD91DBQ28115056-A5152A1A-61EE-4F50-BEF2-6DA21A9D573CQ28115917-4B663A56-09EE-4A07-A429-876C76F083E1Q28118751-F6E3954F-B225-4533-AD78-8A40877A3FE2Q28155857-955A4959-7F8B-4DC4-8530-203B0775BA11Q28941771-BA8DDFC5-0C09-44C8-BCD0-2C1008C8379FQ34538658-A6870114-0733-4734-94EF-B1C83B451620Q35194715-B1C6E9BA-6944-454E-9129-715F56230625Q90465976-AB2C0D66-C0C6-4546-B2EB-0CF48EA115A7
P921
description
Protein in Homo sapiens
@de
mammalian protein found in Homo sapiens
@en
protein
@id
protein
@sv
proteinë
@sq
proteïne in SMAD family member 3
@nl
protèin
@ace
protéine
@fr
بروتين في الإنسان العاقل
@ar
name
SMAD family member 3
@en
type
label
SMAD family member 3
@en
altLabel
JV15-2
@en
MAD homolog 3
@en
MAD, mothers against decapentaplegic homolog 3
@en
SMA- and MAD-related protein 3
@en
SMAD 3
@en
SMAD, mothers against DPP homolog 3
@en
SMAD3
@en
hMAD-3
@en
hSMAD3
@en
mad homolog JV15-2
@en
prefLabel
SMAD family member 3
@en
P361
P527
P637
P638
P672
P680
P681
P682
P705
P352
P486
P672
P352
P486
P637
NP_001138574
NP_001138575
NP_001138576
XP_011519861
XP_011519862
P638
P672
D12.644.360.024.334.500.300
D12.776.157.057.170.500.300
D12.776.260.713.500.300
D12.776.476.024.428.500.300
D12.776.744.741.875
D12.776.930.806.500.300
P680
P681
P682
P702
P703
P705
ENSP00000332973
ENSP00000401133
ENSP00000437757
ENSP00000445348
ENSP00000452767
ENSP00000453082
ENSP00000453684
ENSP00000453788
ENSP00000454165
ENSP00000455095