Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation
about
GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimersLRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complexDifferential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathwaysGTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2GTP binding controls complex formation by the human ROCO protein MASL1Interplay of LRRK2 with chaperone-mediated autophagyThe G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutationG2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarizationActivation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's DiseaseCurrent understanding of LRRK2 in Parkinson's disease: biochemical and structural features and inhibitor designThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseHeterogeneity of leucine-rich repeat kinase 2 mutations: genetics, mechanisms and therapeutic implicationsProgressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in miceParkinson's disease and immune system: is the culprit LRRKing in the periphery?LRRK2 at the interface of autophagosomes, endosomes and lysosomesStructural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contactsThe nitric oxide-cyclic GMP pathway regulates FoxO and alters dopaminergic neuron survival in DrosophilaThe LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions.Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.Arsenite stress down-regulates phosphorylation and 14-3-3 binding of leucine-rich repeat kinase 2 (LRRK2), promoting self-association and cellular redistributionLRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding.Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degenerationRole of LRRK2 kinase dysfunction in Parkinson diseaseRole of LRRK2 kinase activity in the pathogenesis of Parkinson's disease.Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo.Models for LRRK2-Linked Parkinsonism.Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioningMitochondrial dysfunction in genetic animal models of Parkinson's diseaseRegulation of physiologic actions of LRRK2: focus on autophagyGTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.Number and brightness analysis of LRRK2 oligomerization in live cells.Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structuresEvolution of neurodegeneration.The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's diseaseLRRK2 autophosphorylation enhances its GTPase activityKinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicityLRRK2: an éminence grise of Wnt-mediated neurogenesis?LRRK2: cause, risk, and mechanism.
P2860
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P2860
Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Membrane localization of LRRK2 ...... changes in its phosphorylation
@ast
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en-gb
Membrane localization of LRRK2 ...... changes in its phosphorylation
@nl
type
label
Membrane localization of LRRK2 ...... changes in its phosphorylation
@ast
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en-gb
Membrane localization of LRRK2 ...... changes in its phosphorylation
@nl
prefLabel
Membrane localization of LRRK2 ...... changes in its phosphorylation
@ast
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en-gb
Membrane localization of LRRK2 ...... changes in its phosphorylation
@nl
P2093
P2860
P921
P3181
P356
P1433
P1476
Membrane localization of LRRK2 ...... changes in its phosphorylation
@en
P2093
Kelsey A Smith
Matthew J Lavoie
Zdenek Berger
P2860
P304
P3181
P356
10.1021/BI100157U
P407
P577
2010-07-06T00:00:00Z