Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
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The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old ageA two-stage meta-analysis identifies several new loci for Parkinson's diseaseWeb-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's diseaseDJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formationGenetic perspective on the role of the autophagy-lysosome pathway in Parkinson diseaseTransgenic rodent models of Parkinson’s diseaseGenetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateThe genetic epidemiology of neurodegenerative disease.Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumesParkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicityPARK13 regulates PINK1 and subcellular relocation patterns under oxidative stress in neuronsParkin ubiquitinates and promotes the degradation of RanBP2DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosisMutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stabilityParkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageDJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell deathDJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell deathDJ-1 has a role in antioxidative stress to prevent cell deathThe Guanine nucleotide exchange factor kalirin-7 is a novel synphilin-1 interacting protein and modifies synphilin-1 aggregate transport and formationBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaBThe role of oxidative stress in Parkinson's diseaseOxidative status of DJ-1-dependent activation of dopamine synthesis through interaction of tyrosine hydroxylase and 4-dihydroxy-L-phenylalanine (L-DOPA) decarboxylase with DJ-1DJ-1 induces thioredoxin 1 expression through the Nrf2 pathwayParkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationHuman DJ-1 and its homologs are novel glyoxalasesDJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADDA new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsDJ-1 is a copper chaperone acting on SOD1 activationDJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factorStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionHigh-resolution whole-genome association study of Parkinson disease.Genetics of Parkinson diseaseGenome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson diseaseCurcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st centuryA mutation in VPS35, encoding a subunit of the retromer complex, causes late-onset Parkinson diseaseRuns of homozygosity in European populationsThe sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations
P2860
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P2860
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
name
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@ast
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en-gb
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@nl
type
label
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@ast
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en-gb
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@nl
prefLabel
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@ast
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en-gb
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@nl
P2093
P50
P3181
P356
P1433
P1476
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
@en
P2093
Ben A Oostra
Elmar Krieger
Guido J Breedveld
Jeroen W van Dongen
Marieke C J Dekker
Marijke J van Baren
Marijke Joosse
Onno Schaap
Pablo Ibanez
Patrizia Rizzu
P356
10.1126/SCIENCE.1077209
P407
P50
P577
2003-01-10T00:00:00Z