Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update - Test2 - elhamkhani - TriplyDB

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

http://www.wikidata.org/entity/Q22252904

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Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402 Theoretical Approaches to Lentiviral Mediated Neurotrophin Delivery in Potential Treatments of Parkinson's Disease Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism Genetics of Parkinson's disease The genetics and neuropathology of Parkinson's disease Molecular mechanisms of disease-causing missense mutations Genetics of Parkinson's disease - a clinical perspective Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease Mitochondrial Biology and Neurological Diseases Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance Gene-environment interactions: key to unraveling the mystery of Parkinson's disease Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population Disease-toxicant interactions in Parkinson's disease neuropathology Spermidine protects against α-synuclein neurotoxicity.The Protective Effect of Minocycline in a Paraquat-Induced Parkinson's Disease Model in Drosophila is Modified in Altered Genetic Backgrounds.Detection of genomic rearrangements from targeted resequencing data in Parkinson's disease patients Tyrosine hydroxylase gene: another piece of the genetic puzzle of Parkinson's disease Imaging genetics approach to Parkinson's disease and its correlation with clinical score.Efficient allele-specific targeting of LRRK2 R1441 mutations mediated by RNAi.Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease.Mitochondria and neuroplasticity.Phase analysis identifies compound heterozygous deletions of the PARK2 gene in patients with early-onset Parkinson disease.Recent advances in the genetics of Parkinson's disease.Role of LRRK2 kinase dysfunction in Parkinson disease Cooperative genome-wide analysis shows increased homozygosity in early onset Parkinson's disease.PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.Glycyrrhetinic acid and E.resveratroloside act as potential plant derived compounds against dopamine receptor D3 for Parkinson's disease: a pharmacoinformatics study.ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells.DJ-1 Mutations are Rare in a Swedish Parkinson Cohort Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson's disease.Effective variant detection by targeted deep sequencing of DNA pools: an example from Parkinson's disease.Genetic players in multiple system atrophy: unfolding the nature of the beast.DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1.Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease.Breakpoint mapping of 13 large parkin deletions/duplications reveals an exon 4 deletion and an exon 7 duplication as founder mutations.Parkin mutations reduce the complexity of neuronal processes in iPSC-derived human neurons Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes.

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P2860

Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update

http://www.wikidata.org/entity/Q22252904

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Genetic etiology of Parkinson ...... LRRK2 genes: a mutation update

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Creative Commons Attribution 2.5 Unported

P2860

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

DJ-1 has a role in antioxidative stress to prevent cell death

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

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10.1002/HUMU.21277

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Parkinson's disease

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nerve tissue proteins

Parkinson disease associated proteins

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