Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract - Test2 - elhamkhani - TriplyDB

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

http://www.wikidata.org/entity/Q28267110

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Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2 CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration Huntingtin in health and disease PolyQ: a database describing the sequence and domain context of polyglutamine repeats in proteins Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function A novel method for evaluation and screening of caspase inhibitory peptides by the amino acid positional fitness score Huntington's disease: the past, present, and future search for disease modifiers.Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila The crystal structure of caspase-6, a selective effector of axonal degeneration Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6 Drosophila as an In Vivo Model for Human Neurodegenerative Disease Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease Normal huntingtin function: an alternative approach to Huntington's disease Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis Histone acetylation, acetyltransferases, and ataxia--alteration of histone acetylation and chromatin dynamics is implicated in the pathogenesis of polyglutamine-expansion disorders Intracellular aggregation of polypeptides with expanded polyglutamine domain is stimulated by stress-activated kinase MEKK1.Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease.An in vivo assay for the identification of target proteases which cleave membrane-associated substrates.Huntingtin phosphorylation sites mapped by mass spectrometry. Modulation of cleavage and toxicity.Molecular pathogenesis and cellular pathology of spinocerebellar ataxia type 7 neurodegeneration Pathogenesis of inclusion bodies in (CAG)n/Qn-expansion diseases with special reference to the role of tissue transglutaminase and to selective vulnerability.Caspases as treatment targets in stroke and neurodegenerative diseases.Intracellular inclusions, pathological markers in diseases caused by expanded polyglutamine tracts?Complexity and heterogeneity: what drives the ever-changing brain in Huntington's disease?Suicidal tendencies: apoptotic cell death by caspase family proteinases.Polyglutamine pathogenesis.Evidence for both the nucleus and cytoplasm as subcellular sites of pathogenesis in Huntington's disease in cell culture and in transgenic mice expressing mutant huntingtin.Neuromuscular disease and calcium channels.Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models.Oligonucleotide-based strategies to combat polyglutamine diseases.Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease.

P2860

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P2860

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

http://www.wikidata.org/entity/Q28267110

description

1998 nî lūn-bûn

@nan

1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի ապրիլին հրատարակված գիտական հոդված

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年论文

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name

Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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type

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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Journal of Biological Chemistry

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Caspase cleavage of gene produ ...... aining the polyglutamine tract

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A Kakizuka

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A S Hackam

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C A Ross

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C L Wellington

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K J Rowland

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K McCutcheon

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P2860

Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

Functional domains and upstream activation properties of cloned human TATA binding protein

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

Expanded polyglutamine in the Machado-Joseph disease protein induces cell death in vitro and in vivo

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

DRPLA gene (atrophin-1) sequence and mRNA expression in human brain

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15

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