Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response
about
Spartan/C1orf124 is important to prevent UV-induced mutagenesisProliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesisDVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocksDVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damagePRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryTranscriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesisThe Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like ModifiersFunctions of Ubiquitin and SUMO in DNA Replication and Replication StressRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinCharacterization of human Spartan/C1orf124, an ubiquitin-PCNA interacting regulator of DNA damage toleranceWss1 metalloprotease partners with Cdc48/Doa1 in processing genotoxic SUMO conjugatesA widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotesHow Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend InitiativeRole of PCNA and TLS polymerases in D-loop extension during homologous recombination in humansChromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.DNA-dependent protease activity of human Spartan facilitates replication of DNA-protein crosslink-containing DNA.Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.Parkin regulates translesion DNA synthesis in response to UV radiationNon-canonical CRL4A/4B(CDT2) interacts with RAD18 to modulate post replication repair and cell survival.Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.Spartan deficiency causes genomic instability and progeroid phenotypes.Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid featuresRelevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication StressA non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forksRole of p97/VCP (Cdc48) in genome stability.DNA damage tolerance: a double-edged sword guarding the genomeMechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.Mechanisms of Post-Replication DNA RepairQuantitative microscopy uncovers ploidy changes during mitosis in live Drosophila embryos and their effect on nuclear size.Readers of PCNA modificationsThe identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.What is the DNA repair defect underlying Fanconi anemia?Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.Regulation of error-prone translesion synthesis by Spartan/C1orf124.
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Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response
description
2012 nî lūn-bûn
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2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
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2012 թվականի հունիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@ast
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en-gb
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@nl
type
label
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@ast
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en-gb
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@nl
prefLabel
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@ast
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en-gb
Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@nl
P2093
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Spartan/C1orf124, a reader of ...... UV-induced DNA damage response
@en
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Richard C Centore
Stephanie A Yazinski
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P304
P3181
P356
10.1016/J.MOLCEL.2012.05.020
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P577
2012-06-08T00:00:00Z