Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis
about
PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitryTranscriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesisRing of Change: CDC48/p97 Drives Protein Dynamics at ChromatinBalancing self-renewal against genome preservation in stem cells: How do they manage to have the cake and eat it too?Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity.DNA-dependent protease activity of human Spartan facilitates replication of DNA-protein crosslink-containing DNA.Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis.SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.Spartan deficiency causes genomic instability and progeroid phenotypes.Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid featuresRelevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance.PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication StressAlpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress.DNA polymerases κ and ζ cooperatively perform mutagenic translesion synthesis of the C8-2'-deoxyguanosine adduct of the dietary mutagen IQ in human cellsRole of p97/VCP (Cdc48) in genome stability.DNA damage tolerance: a double-edged sword guarding the genomeMechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN.Mismatch repair protein MSH2 regulates translesion DNA synthesis following exposure of cells to UV radiation.Quantitative microscopy uncovers ploidy changes during mitosis in live Drosophila embryos and their effect on nuclear size.Readers of PCNA modificationsThe identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.Strategic role of the ubiquitin-dependent segregase p97 (VCP or Cdc48) in DNA replication.The role of WRNIP1 in genome maintenanceMaintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases.Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.Regulation of error-prone translesion synthesis by Spartan/C1orf124.Translesion Synthesis of the N(2)-2'-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1.SPRTN is a mammalian DNA-binding metalloprotease that resolves DNA-protein crosslinks.Metalloprotease SPRTN/DVC1 Orchestrates Replication-Coupled DNA-Protein Crosslink Repair.Mutational analysis of the C8-guanine adduct of the environmental carcinogen 3-nitrobenzanthrone in human cells: critical roles of DNA polymerases η and κ and Rev1 in error-prone translesion synthesis.Differential RPA-1 and RAD-51 recruitment in vivo throughout the C. elegans germline, as revealed by laser microirradiation.Formation and repair of DNA-protein crosslink damage.Maternal Haploid, a Metalloprotease Enriched at the Largest Satellite Repeat and Essential for Genome Integrity in Drosophila Embryos.SPRTN binds monoUb:K164-PCNA associated with POLHSPRTN recruits VCP to monoUb:K164-PCNA associated with POLHDNA protein crosslink proteolysis repair: From yeast to premature ageing and cancer in humans
P2860
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P2860
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis
description
2012 nî lūn-bûn
@nan
2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Proliferating cell nuclear ant ...... lator of translesion synthesis
@ast
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en-gb
Proliferating cell nuclear ant ...... lator of translesion synthesis
@nl
type
label
Proliferating cell nuclear ant ...... lator of translesion synthesis
@ast
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en-gb
Proliferating cell nuclear ant ...... lator of translesion synthesis
@nl
prefLabel
Proliferating cell nuclear ant ...... lator of translesion synthesis
@ast
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en-gb
Proliferating cell nuclear ant ...... lator of translesion synthesis
@nl
P2093
P2860
P921
P3181
P356
P1476
Proliferating cell nuclear ant ...... lator of translesion synthesis
@en
P2093
Binoj C Nair
Gargi Ghosal
Junjie Chen
Justin Wai-Chung Leung
P2860
P304
P3181
P356
10.1074/JBC.M112.400135
P407
P50
P577
2012-10-05T00:00:00Z