SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
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Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic ImplicationsCul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implicationsInvolvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma.The emerging role of speckle-type POZ protein (SPOP) in cancer development.Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesisSerum Autoantibodies in Chronic Prostate Inflammation in Prostate Cancer Patients.Nanobody-targeted E3-ubiquitin ligase complex degrades nuclear proteinsSPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylaseMultiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.Speckle-type POZ (pox virus and zinc finger protein) protein gene deletion in ovarian cancer: Fluorescence in situ hybridization analysis of a tissue microarrayHigher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancerDysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer.Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.Gene Expression in Mouse Thyrotrope Adenoma: Transcription Elongation Factor Stimulates Proliferation.Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.Structure-function analysis of the Fusarium oxysporum Avr2 effector allows uncoupling of its immune-suppressing activity from recognition.RNA interference-mediated silencing of speckle-type POZ protein promotes apoptosis of renal cell cancer cells.Importin-11 keeps PTEN safe from harm.Linc-RoR promotes MAPK/ERK signaling and confers estrogen-independent growth of breast cancer.Ubiquitin ligases in oncogenic transformation and cancer therapy.MACC1 supports human gastric cancer growth under metabolic stress by enhancing the Warburg effect.Speckle-Type POZ Protein Down-Regulates Matrix Metalloproteinase 2 Expression via Sp1/PI3K/Akt Signaling Pathway in Colorectal Cancer.SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors.A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing.Targeting SPOP with small molecules provides a novel strategy for kidney cancer therapy.SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.Speckle-type POZ protein is negatively associated with malignancies and inhibits cell proliferation and migration in liver cancer.Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability
P2860
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P2860
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
description
2014 nî lūn-bûn
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2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2014 թվականի ապրիլին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
@yue
2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@ast
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en-gb
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@nl
type
label
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@ast
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en-gb
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@nl
altLabel
SPOP Promotes Tumorigenesis by Acting as a Key Regulatory Hub in Kidney Cancer
@en
prefLabel
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@ast
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en-gb
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@nl
P2093
P2860
P50
P3181
P1433
P1476
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer
@en
P2093
Carrie Rinker-Schaeffer
Edmond R Watson
Guoqiang Li
Kevin P White
Liqun Zhou
Matthew F Calabrese
Min Zhuang
P2860
P304
P3181
P356
10.1016/J.CCR.2014.02.007
P407
P5008
P577
2014-03-20T00:00:00Z