Mitochondrial DNA ligase III function is independent of Xrcc1. - Test2 - elhamkhani - TriplyDB

Mitochondrial DNA ligase III function is independent of Xrcc1.

Mitochondrial DNA ligase III function is independent of Xrcc1.

http://www.wikidata.org/entity/Q24523954

about

Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair Eukaryotic DNA ligases: structural and functional insights Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair Repair of persistent strand breaks in the mitochondrial genome Early embryonic lethality due to targeted inactivation of DNA ligase III DNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks.DNA damage related crosstalk between the nucleus and mitochondria.Mitochondrial DNA repair and association with aging--an update DNA repair deficiency in neurodegeneration.Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.Interaction of DNA repair gene polymorphisms and aflatoxin B1 in the risk of hepatocellular carcinoma.DNA ligases as therapeutic targets Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIalpha.XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibility Disconnecting XRCC1 and DNA ligase III Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining Mitochondrial DNA, base excision repair and neurodegeneration.Repair of mitochondrial DNA in aging and carcinogenesis.'To repair or not to repair - no longer a question': repair of mitochondrial DNA shielding against age and cancer.Mitochondrial DNA damage and the aging process: facts and imaginations.Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous mice Base excision repair in the mammalian brain: implication for age related neurodegeneration DNA repair deficiency and neurological disease.HMGA1 levels influence mitochondrial function and mitochondrial DNA repair efficiency Nuclear and mitochondrial DNA oxidation in Alzheimer's disease.Mitochondrial DNA maintenance: an appraisal.Mitochondrial DNA ligase function in Saccharomyces cerevisiae.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Coordination of DNA single strand break repair.A novel interaction between DNA ligase III and DNA polymerase gamma plays an essential role in mitochondrial DNA stability.Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes.Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.Kinetic analyses of single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I.The Role of DNA Repair in Maintaining Mitochondrial DNA Stability.

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P2860

Mitochondrial DNA ligase III function is independent of Xrcc1.

http://www.wikidata.org/entity/Q24523954

description

2000 nî lūn-bûn

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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Mitochondrial DNA ligase III function is independent of Xrcc1

@nl

Mitochondrial DNA ligase III function is independent of Xrcc1.

@ast

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en-gb

type

label

Mitochondrial DNA ligase III function is independent of Xrcc1

@nl

Mitochondrial DNA ligase III function is independent of Xrcc1.

@ast

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en-gb

prefLabel

Mitochondrial DNA ligase III function is independent of Xrcc1

@nl

Mitochondrial DNA ligase III function is independent of Xrcc1.

@ast

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en-gb

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Nucleic Acids Research

P1476

Mitochondrial DNA ligase III function is independent of Xrcc1.

@en

P2093

C Campbell

http://www.w3.org/2001/XMLSchema#string

U Lakshmipathy

http://www.w3.org/2001/XMLSchema#string

P2860

The human DNA ligase III gene encodes nuclear and mitochondrial proteins

Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage

Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein

An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III

Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Solution structure of the single-strand break repair protein XRCC1 N-terminal domain

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3880-3886

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scholarly article

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10.1093/NAR/28.20.3880

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20

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28

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2000-10-01T00:00:00Z

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12299994

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11024166

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mitochondrial DNA

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110795

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