Mitochondrial DNA ligase III function is independent of Xrcc1.
about
Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repairCrucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repairDNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repairEukaryotic DNA ligases: structural and functional insightsHuman DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound statesPhysical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repairRepair of persistent strand breaks in the mitochondrial genomeEarly embryonic lethality due to targeted inactivation of DNA ligase IIIDNA ligase 1 deficient plants display severe growth defects and delayed repair of both DNA single and double strand breaks.DNA damage related crosstalk between the nucleus and mitochondria.Mitochondrial DNA repair and association with aging--an updateDNA repair deficiency in neurodegeneration.Structure and function of the DNA ligases encoded by the mammalian LIG3 gene.Interaction of DNA repair gene polymorphisms and aflatoxin B1 in the risk of hepatocellular carcinoma.DNA ligases as therapeutic targetsPartial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIalpha.XRCC1 haploinsufficiency in mice has little effect on aging, but adversely modifies exposure-dependent susceptibilityDisconnecting XRCC1 and DNA ligase IIISlow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joiningMitochondrial DNA, base excision repair and neurodegeneration.Repair of mitochondrial DNA in aging and carcinogenesis.'To repair or not to repair - no longer a question': repair of mitochondrial DNA shielding against age and cancer.Mitochondrial DNA damage and the aging process: facts and imaginations.Mutagenesis is elevated in male germ cells obtained from DNA polymerase-beta heterozygous miceBase excision repair in the mammalian brain: implication for age related neurodegenerationDNA repair deficiency and neurological disease.HMGA1 levels influence mitochondrial function and mitochondrial DNA repair efficiencyNuclear and mitochondrial DNA oxidation in Alzheimer's disease.Mitochondrial DNA maintenance: an appraisal.Mitochondrial DNA ligase function in Saccharomyces cerevisiae.Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?Coordination of DNA single strand break repair.A novel interaction between DNA ligase III and DNA polymerase gamma plays an essential role in mitochondrial DNA stability.Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes.Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.Kinetic analyses of single-stranded break repair by human DNA ligase III isoforms reveal biochemical differences from DNA ligase I.The Role of DNA Repair in Maintaining Mitochondrial DNA Stability.
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P2860
Mitochondrial DNA ligase III function is independent of Xrcc1.
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Mitochondrial DNA ligase III function is independent of Xrcc1
@nl
Mitochondrial DNA ligase III function is independent of Xrcc1.
@ast
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en-gb
type
label
Mitochondrial DNA ligase III function is independent of Xrcc1
@nl
Mitochondrial DNA ligase III function is independent of Xrcc1.
@ast
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en-gb
prefLabel
Mitochondrial DNA ligase III function is independent of Xrcc1
@nl
Mitochondrial DNA ligase III function is independent of Xrcc1.
@ast
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en-gb
P2860
P356
P1476
Mitochondrial DNA ligase III function is independent of Xrcc1.
@en
P2093
C Campbell
U Lakshmipathy
P2860
P304
P356
10.1093/NAR/28.20.3880
P407
P577
2000-10-01T00:00:00Z