A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
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The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesionDNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchangeWhat goes on must come off: phosphatases gate-crash the DNA damage responseRPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage responseProtein phosphatase 4 promotes chromosome pairing and synapsis, and contributes to maintaining crossover competence with increasing ageThe DNA Damage Response: Making It Safe to Play with KnivesProtein phosphatases pph3, ptc2, and ptc3 play redundant roles in DNA double-strand break repair by homologous recombination.MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stabilityPP4 is essential for germinal center formation and class switch recombination in miceProtein Ser/Thr phosphatases--the ugly ducklings of cell signalling.Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.Distinct phosphatases antagonize the p53 response in different phases of the cell cycleRFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks.ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot.Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells.RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.Interplay of DNA damage and cell cycle signaling at the level of human replication protein APhosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery.miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.Loss of CCDC6, the first identified RET partner gene, affects pH2AX S139 levels and accelerates mitotic entry upon DNA damage.Rfa2 is specifically dephosphorylated by Pph3 in Candida albicans.The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination.Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication.Phosphorylation and cellular function of the human Rpa2 N-terminus in the budding yeast Saccharomyces cerevisiae.The DNA damage response and checkpoint adaptation in Saccharomyces cerevisiae: distinct roles for the replication protein A2 (Rfa2) N-terminus.Regulation of Rfa2 phosphorylation in response to genotoxic stress in Candida albicans.Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cellsDephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular FunctionsHomologous recombination and its regulationLentivirus-Mediated Short-Hairpin RNA Targeting Protein Phosphatase 4 Regulatory Subunit 1 Inhibits Growth in Breast Cancer.Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma.Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.Controlling DNA-end resection: a new task for CDKs.Key clinical beam parameters for nanoparticle-mediated radiation dose amplification.Serine/threonine phosphatases in the DNA damage response and cancer.Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion.Role of genome guardian proteins in transcriptional elongation.Polymerase δ-interacting Protein 2: A Multifunctional Protein.The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.A phosphorylation-and-ubiquitylation circuitry driving ATR activation and homologous recombination.
P2860
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P248
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P2860
A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination
description
2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
A PP4 phosphatase complex deph ...... r via homologous recombination
@ast
A PP4 phosphatase complex deph ...... r via homologous recombination
@en
A PP4 phosphatase complex deph ...... r via homologous recombination
@en-gb
A PP4 phosphatase complex deph ...... r via homologous recombination
@nl
type
label
A PP4 phosphatase complex deph ...... r via homologous recombination
@ast
A PP4 phosphatase complex deph ...... r via homologous recombination
@en
A PP4 phosphatase complex deph ...... r via homologous recombination
@en-gb
A PP4 phosphatase complex deph ...... r via homologous recombination
@nl
prefLabel
A PP4 phosphatase complex deph ...... r via homologous recombination
@ast
A PP4 phosphatase complex deph ...... r via homologous recombination
@en
A PP4 phosphatase complex deph ...... r via homologous recombination
@en-gb
A PP4 phosphatase complex deph ...... r via homologous recombination
@nl
P2093
P2860
P921
P3181
P356
P1476
A PP4 phosphatase complex deph ...... r via homologous recombination
@en
P2093
Dipanjan Chowdhury
Dong-Hyun Lee
James A Borowiec
Patrick Sung
Shlomo Kanner
Yunfeng Pan
P2860
P2888
P304
P3181
P356
10.1038/NSMB.1769
P407
P577
2010-03-01T00:00:00Z
P5875
P6179
1041506627