MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function - Test2 - elhamkhani - TriplyDB

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

http://www.wikidata.org/entity/Q24540167

about

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL Redox regulation of FoxO transcription factors Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment Identification and analysis of evolutionary selection pressures acting at the molecular level in five forkhead subfamilies.The FOX transcription factors regulate vascular pathology, diabetes and Tregs Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma.Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-κB and transcription regulatory factors.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.The many forks in FOXO's road.Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty.The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-β pathway.MLL fusions: pathways to leukemia Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9 PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis.The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia.In control of biology: of mice, men and Foxes Ras as a therapeutic target in hematologic malignancies.Review: genetic models of acute myeloid leukaemia.miR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Role of protein-protein interactions in the antiapoptotic function of EWS-Fli-1.Molecular mechanisms of MLL-associated leukemia.FOXO transcription factors in cancer development and therapy.Forkhead followed by disordered tail: The intrinsically disordered regions of FOXO3a.Protein arginine-methyltransferase-dependent oncogenesis.Transcriptional activation is a key function encoded by MLL fusion partners.Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.FOXO in Neural Cells and Diseases of the Nervous System.The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice.

P2860

Q24299122-F318B8A7-FA2B-4407-9EE6-2B44132C0E86 Q24603527-F3E9CD17-3B7E-4DCA-8283-1A13902B338B Q24675588-50943D8C-E08B-47DF-88F5-5974BBD7EEA2 Q26799843-BFEED19B-19AC-4C9A-8EC9-A6578C9781A0 Q27678321-9DE8D529-FB64-4B93-8DD9-58512C7B0848 Q33371818-D72A2AAD-5993-4BE4-8590-0BC1EC34D53E Q33763033-8DA9BCC7-E7B9-45F7-B5B8-8945B4ED7C68 Q33997220-EA522CB2-6BB6-4A4E-9FF7-AB61F5C611D7 Q34035076-001DCEC7-8F50-43E9-89C3-F2486846DE89 Q34210060-F45E8320-AD55-4653-AA7A-F31E36C3BE05 Q34553972-ED215AC7-AFC7-4A87-BAC1-9E126DFB1594 Q34581540-B8828E31-A612-4361-9A0A-CFAB6FE9CC97 Q35079447-33CEC970-5112-477E-9CC6-2A9CB4FB7AD0 Q35139549-9BF27B8A-34A3-4C2E-8DBB-CCFBFE42027C Q35586103-72AA69CC-95A4-4511-8090-3FBCEFD5BF22 Q35788362-C80A7626-E8FA-4FC7-94B4-6B107355F58A Q35948212-4A393D1C-1002-48EA-BB8E-D11D058E9CED Q35971222-403C75C5-65FE-40D1-8107-3365467D1142 Q36010294-13AABFE1-976E-42F3-94D4-1C331F99871A Q36098242-0D5077C7-EFFA-4A4B-AB1B-22A1CCFCABF5 Q36334327-41215130-3DDB-4A88-BB40-21315B12EDB1 Q36508924-10D5B7F8-7A84-4465-89C7-4E094AFBF9F1 Q36515335-80BBB89F-8AE0-437A-845E-A6A18DC1F396 Q36866611-FE3254CC-2E84-492E-B014-6A15DB6BDCAC Q37080843-3AA03E8F-7C6F-42E5-AD5E-C35068F65407 Q37330835-6E355D6B-22A6-4B19-B3A7-F2377140267A Q37622891-C79E0D9F-7453-4C05-A8D5-B6A9B985EB3B Q38161393-1274DECC-0D96-46C1-9EC0-0A52A387CE4D Q38338516-C9839AE2-B731-4875-ADD4-BB13BD2885E0 Q38379210-CFBED9B2-7CE6-48E6-AFEC-8261D2EA50BD Q38674456-28B90DBD-955D-4EE9-935E-6FD10006066F Q39000854-92E7764D-8EB3-4DAD-8CE8-EA25752C6B6C Q40077054-1E97460D-C220-4049-9145-7B1FCA316D21 Q40669934-D3EC656A-F2DD-43DE-9C87-B5C8E710D181 Q42176903-B54BCFC0-7FE6-434F-9B36-0247C2BEEDAA Q50057277-14F9C75C-3092-4AEC-963C-10727EB76174 Q53607290-8D096D23-F532-48CC-8177-3B75683FC83F

P2860

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

http://www.wikidata.org/entity/Q24540167

description

2002 nî lūn-bûn

@nan

2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2002年の論文

@ja

2002年論文

@yue

2002年論文

@zh-hant

2002年論文

@zh-hk

2002年論文

@zh-mo

2002年論文

@zh-tw

2002年论文

@wuu

name

MLL-AFX requires the transcrip ...... with forkhead protein function

@ast

MLL-AFX requires the transcrip ...... with forkhead protein function

@en

MLL-AFX requires the transcrip ...... with forkhead protein function

@nl

type

label

MLL-AFX requires the transcrip ...... with forkhead protein function

@ast

MLL-AFX requires the transcrip ...... with forkhead protein function

@en

MLL-AFX requires the transcrip ...... with forkhead protein function

@nl

prefLabel

MLL-AFX requires the transcrip ...... with forkhead protein function

@ast

MLL-AFX requires the transcrip ...... with forkhead protein function

@en

MLL-AFX requires the transcrip ...... with forkhead protein function

@nl

P1433

Q24540167-D2FDC728-0D49-4142-B22B-931F5038F5F9

P1476

Q24540167-81D9E81D-1EBA-43D8-81A1-97A193AA3933

P2093

Q24540167-35A148BF-1BE3-44C2-A674-E55C39056541

Q24540167-72150183-CDA4-46CE-AEE1-491A27C7F501

P2860

Q24540167-12E4786E-E018-478A-B2B0-F07EE4BB67FE

Q24540167-19F1D43B-9C83-41ED-AD9E-5248818419C9

Q24540167-1F6C0FC0-0BAA-4CDD-9B2C-D6160A333274

Q24540167-1FCF3FD7-A04A-4F00-9B07-67E4D2D75D3E

Q24540167-2051F9A2-8347-4604-B911-EE697326241D

Q24540167-2470F3AE-EAD4-4F1E-B13C-5B345DAF0FBE

Q24540167-2477738B-AF0A-4217-83BF-57D741A38267

Q24540167-27A2D5B4-A94F-4078-8300-0C00CA64F322

Q24540167-2E1B165D-DF76-4617-8FB5-A8B3E0641C0B

Q24540167-32A87823-F842-4F58-86A2-2BCC48DA77AD

P304

Q24540167-323DC2C1-6AAF-4EC5-BD57-FE8CF243C7CC

P31

Q24540167-AA5AC909-534D-4923-AACC-81416FDD4DBC

P3181

Q24540167-F66E905F-A9A1-4A56-8E11-0B093D981858

P356

Q24540167-E5F59D51-58A6-42D2-A151-0D8F4F137FB3

P407

Q24540167-9267CB29-368C-4C5A-BB5C-A9CC3D70145C

P433

Q24540167-4172A425-1A6C-45EB-BFDB-9D694277495F

P478

Q24540167-8E4EB0EC-26FB-46FD-A3FB-961161B9ABAB

P577

Q24540167-1BB14E30-964C-45E1-8C61-64F7915E0AD9

P5875

Q24540167-F313D285-B80C-4098-A1C4-B17DF66270B4

P698

Q24540167-734F2FFA-BC50-4EA7-A6F9-1C5D8B9429EE

P921

Q24540167-32C1D0C6-632B-477D-B998-432B068E4C69

P932

Q24540167-EE732469-279F-4B32-9A44-575F7BA11ABC

P3181

P356

MCB.22.18.6542-6552.2002

P1433

Molecular and Cellular Biology

P1476

MLL-AFX requires the transcrip ...... with forkhead protein function

@en

P2093

Chi Wai So

http://www.w3.org/2001/XMLSchema#string

Michael L Cleary

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Direct control of the Forkhead transcription factor AFX by protein kinase B

The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Interaction of the pRB-family proteins with factors containing paired-like homeodomains

ENL, the gene fused with HRX in t(11;19) leukemias, encodes a nuclear protein with transcriptional activation potential in lymphoid and myeloid cells

The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis

Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9

P304

6542-52

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

3375869

http://www.w3.org/2001/XMLSchema#string

P356

10.1128/MCB.22.18.6542-6552.2002

http://www.w3.org/2001/XMLSchema#string

P407

P433

18

http://www.w3.org/2001/XMLSchema#string

P478

22

http://www.w3.org/2001/XMLSchema#string

P577

2002-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

11196194

http://www.w3.org/2001/XMLSchema#string

P698

12192052

http://www.w3.org/2001/XMLSchema#string

P921

P932

135648

http://www.w3.org/2001/XMLSchema#string