Protein arginine-methyltransferase-dependent oncogenesis. - Test2 - elhamkhani - TriplyDB

Protein arginine-methyltransferase-dependent oncogenesis.

Protein arginine-methyltransferase-dependent oncogenesis.

http://www.wikidata.org/entity/Q40077054

about

CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis Identification of a Sam68 ribonucleoprotein complex regulated by epidermal growth factor Epimutational profile of hematologic malignancies as attractive target for new epigenetic therapies SAM68: Signal Transduction and RNA Metabolism in Human Cancer Arginine methyltransferases as novel therapeutic targets for breast cancer Current chemical biology approaches to interrogate protein methyltransferases Sam68 Is Required for DNA Damage Responses via Regulating Poly(ADP-ribosyl)ation Protein arginine methylation in mammals: who, what, and why An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization.Targeting Aberrant Epigenetic Networks Mediated by PRMT1 and KDM4C in Acute Myeloid Leukemia.Reconstructing networks of pathways via significance analysis of their intersections.PRMT8 demonstrates variant-specific expression in cancer cells and correlates with patient survival in breast, ovarian and gastric cancer.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Histone arginine methylations: their roles in chromatin dynamics and transcriptional regulation.Epigenetics: an emerging player in gastric cancer H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex.Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.Chemical and biochemical approaches in the study of histone methylation and demethylation Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding Synthesis and evaluation of carbocyanine dyes as PRMT inhibitors and imaging agents.Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.Arginine methylation of BCL-2 antagonist of cell death (BAD) counteracts its phosphorylation and inactivation by Akt.Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Selective inhibitors of protein methyltransferases Virtual screening and biological evaluation of novel small molecular inhibitors against protein arginine methyltransferase 1 (PRMT1).TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression Chemical biology of protein arginine modifications in epigenetic regulation MLL fusions: pathways to leukemia Arginine methylation-dependent regulation of ASK1 signaling by PRMT1 PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential The pathogenesis of mixed-lineage leukemia.An essential and evolutionarily conserved role of protein arginine methyltransferase 1 for adult intestinal stem cells during postembryonic development.Correlation of SRSF1 and PRMT1 expression with clinical status of pediatric acute lymphoblastic leukemia

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P2860

Protein arginine-methyltransferase-dependent oncogenesis.

http://www.wikidata.org/entity/Q40077054

description

2007 nî lūn-bûn

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2007年の論文

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2007年學術文章

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Protein arginine-methyltransferase-dependent oncogenesis.

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Protein arginine-methyltransferase-dependent oncogenesis.

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Protein arginine-methyltransferase-dependent oncogenesis.

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Nature Cell Biology

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Protein arginine-methyltransferase-dependent oncogenesis.

@en

P2093

Chi Wai Eric So

http://www.w3.org/2001/XMLSchema#string

Li Chong Chan

http://www.w3.org/2001/XMLSchema#string

Michael L Cleary

http://www.w3.org/2001/XMLSchema#string

Ngai Cheung

http://www.w3.org/2001/XMLSchema#string

P2860

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

TAB3, a new binding partner of the protein kinase TAK1

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein

EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia

Histone arginine methylation regulates pluripotency in the early mouse embryo

Chromatin modifications and their function

hDOT1L links histone methylation to leukemogenesis.

Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53

MLL targets SET domain methyltransferase activity to Hox gene promoters

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1208-1215

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scholarly article

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10.1038/NCB1642

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10

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9

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2007-09-23T00:00:00Z

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5953376

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17891136

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