Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9 - Test2 - elhamkhani - TriplyDB

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

http://www.wikidata.org/entity/Q35971222

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Implication of IRF4 aberrant gene expression in the acute leukemias of childhood Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis Global and Hox-specific roles for the MLL1 methyltransferase The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.Identification and characterization of Hoxa9 binding sites in hematopoietic cells The miR-17-92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics NUP98 dysregulation in myeloid leukemogenesis Evidence that the Pim1 kinase gene is a direct target of HOXA9 Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia AML1/ETO proteins control POU4F1/BRN3A expression and function in t(8;21) acute myeloid leukemia ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.Classifying leukemia types with chromatin conformation data.Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes.Chromatin conformation signatures of cellular differentiation Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Epigenetics: an emerging player in gastric cancer Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease.Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia Mll fusions generated by Cre-loxP-mediated de novo translocations can induce lineage reassignment in tumorigenesis Three-dimensional modeling of chromatin structure from interaction frequency data using Markov chain Monte Carlo sampling.Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia.NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

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P2860

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

http://www.wikidata.org/entity/Q35971222

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

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2003年论文

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2003年论文

@zh-cn

name

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

@ast

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

@en

type

label

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

@ast

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

@en

prefLabel

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

@ast

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

@en

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Genes & Development

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Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9

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Michael L Cleary

http://www.w3.org/2001/XMLSchema#string

Paul M Ayton

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P2860

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia

Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells

Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae

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2298-2307

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scholarly article

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10.1101/GAD.1111603

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18

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17

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2003-09-02T00:00:00Z

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10584995

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12952893

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196466

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