Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.
about
Recent progress toward epigenetic therapies: the example of mixed lineage leukemiaHistone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.A short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner.Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l.Differential regulation of the c-Myc/Lin28 axis discriminates subclasses of rearranged MLL leukemiaMolecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.Molecular mechanisms of MLL-associated leukemia.Epigenetic control of gene expression in leukemogenesis: Cooperation between wild type MLL and MLL fusion proteins.Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression.Loss of AF6/afadin, a marker of poor outcome in breast cancer, induces cell migration, invasiveness and tumor growth.Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.s-Afadin binds more preferentially to the cell adhesion molecules nectins than l-afadin.The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia.
P2860
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P2860
Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Self-association mediated by t ...... ncogenic potential of MLL-AF6.
@ast
Self-association mediated by t ...... ncogenic potential of MLL-AF6.
@en
type
label
Self-association mediated by t ...... ncogenic potential of MLL-AF6.
@ast
Self-association mediated by t ...... ncogenic potential of MLL-AF6.
@en
prefLabel
Self-association mediated by t ...... ncogenic potential of MLL-AF6.
@ast
Self-association mediated by t ...... ncogenic potential of MLL-AF6.
@en
P2093
P2860
P1433
P1476
Self-association mediated by t ...... oncogenic potential of MLL-AF6
@en
P2093
Kevin S Smith
Michael L Cleary
Michaela Liedtke
Paul M Ayton
P2860
P356
10.1182/BLOOD-2009-09-243386
P407
P577
2010-04-15T00:00:00Z