Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress - Test2 - elhamkhani - TriplyDB

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

http://www.wikidata.org/entity/Q24559993

about

The hSNM1 protein is a DNA 5'-exonuclease MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway SNMIB/Apollo protects leading-strand telomeres against NHEJ-mediated repair microRNA-34a promotes DNA damage and mitotic catastrophe.Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation.The multifunctional SNM1 gene family: not just nucleases 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection.The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.hSnm1B is a novel telomere-associated protein.Nucleases of the metallo-beta-lactamase family and their role in DNA and RNA metabolism.Tying the loose ends together in DNA double strand break repair with 53BP1.Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27 CHFR: A Novel Mitotic Checkpoint Protein and Regulator of Tumorigenesis.Mammalian SNM1 is required for genome stability.Bufalin alters gene expressions associated DNA damage, cell cycle, and apoptosis in human lung cancer NCI-H460 cells in vitro.Human KIAA1018/FAN1 nuclease is a new mitotic substrate of APC/C(Cdh1)SNM1A acts downstream of ATM to promote the G1 cell cycle checkpoint Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links.Nek7 kinase targeting leads to early mortality, cytokinesis disturbance and polyploidy.

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Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

http://www.wikidata.org/entity/Q24559993

description

2004 nî lūn-bûn

@nan

2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@ast

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@en

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@nl

type

label

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@ast

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@en

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@nl

prefLabel

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@ast

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@en

Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@nl

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MCB.24.23.10448-10455.2004

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Molecular and Cellular Biology

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Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

@en

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Charles Patrick

http://www.w3.org/2001/XMLSchema#string

Christopher T Richie

http://www.w3.org/2001/XMLSchema#string

Eric Brey

http://www.w3.org/2001/XMLSchema#string

Jian Min Deng

http://www.w3.org/2001/XMLSchema#string

Randy J Legerski

http://www.w3.org/2001/XMLSchema#string

Richard R Behringer

http://www.w3.org/2001/XMLSchema#string

Shamima Akhter

http://www.w3.org/2001/XMLSchema#string

Xiaoshan Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex

Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I

Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family.

hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage

Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

A candidate prostate cancer susceptibility gene at chromosome 17p

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10448-10455

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scholarly article

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10.1128/MCB.24.23.10448-10455.2004

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23

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2004-12-01T00:00:00Z

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15542852

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