The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.
about
Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105Cdc123 and checkpoint forkhead associated with RING proteins control the cell cycle by controlling eIF2gamma abundanceThe tumor suppressor CYLD regulates entry into mitosisPML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint proteinChfr is linked to tumour metastasis through the downregulation of HDAC1Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stressG2E3 is a dual function ubiquitin ligase required for early embryonic developmentEpigenetic inactivation of CHFR in human tumorsp190RhoGAP is cell cycle regulated and affects cytokinesis.Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cellsMaintaining Genome Stability in Defiance of Mitotic DNA DamagePellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1Structural basis of poly(ADP-ribose) recognition by the multizinc binding domain of checkpoint with forkhead-associated and RING Domains (CHFR)Functional characterization of Dma1 and Dma2, the budding yeast homologues of Schizosaccharomyces pombe Dma1 and human ChfrYeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination.Role of E3 ubiquitin ligases in gastric cancerChfr inactivation is not associated to chromosomal instability in colon cancersThe Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chainsUbiquitin and SUMO systems in the regulation of mitotic checkpointsChfr is required for tumor suppression and Aurora A regulationPolo-like kinases and the orchestration of cell divisionCotargeting HSP90 and Its Client Proteins for Treatment of Prostate Cancer.Targeting TCTP as a new therapeutic strategy in castration-resistant prostate cancer.Dma1 ubiquitinates the SIN scaffold, Sid4, to impede the mitotic localization of Plo1 kinase.The anti-proliferative effects of the CHFR depend on the forkhead associated domain, but not E3 ligase activity mediated by ring finger domain.Safeguarding entry into mitosis: the antephase checkpoint.Epigenetic and genetic silencing of CHFR in esophageal adenocarcinomas.Curcumin-induced mitotic arrest is characterized by spindle abnormalities, defects in chromosomal congression and DNA damage.The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr.Control of the centriole and centrosome cycles by ubiquitination enzymes.The auto-ubiquitylation of E3 ubiquitin-protein ligase Chfr at G2 phase is required for accumulation of polo-like kinase 1 and mitotic entry in mammalian cells.DNA damage checkpoint control in cells exposed to ionizing radiation.Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection.RNA interference-mediated silencing of the polo-like kinase 1 gene enhances chemosensitivity to gemcitabine in pancreatic adenocarcinoma cells.CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation.Xenopus Polo-like kinase Plx1: a multifunctional mitotic kinase.Regulation of cell cycle checkpoints by polo-like kinases.Dnt1 acts as a mitotic inhibitor of the spindle checkpoint protein dma1 in fission yeastThe Cech Symposium: a celebration of 25 years of ribozymes, 10 years of TERT, and 60 years of Tom.Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer
P2860
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P2860
The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The checkpoint protein Chfr is ...... Cdc2 at the G2 to M transition
@nl
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@ast
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@en
type
label
The checkpoint protein Chfr is ...... Cdc2 at the G2 to M transition
@nl
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@ast
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@en
prefLabel
The checkpoint protein Chfr is ...... Cdc2 at the G2 to M transition
@nl
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@ast
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@en
P2093
P2860
P3181
P356
P1476
The checkpoint protein Chfr is ...... dc2 at the G2 to M transition.
@en
P2093
Dongmin Kang
Guowei Fang
James Chen
P2860
P304
P3181
P356
10.1083/JCB.200108016
P407
P577
2002-01-21T00:00:00Z