Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation
about
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.LRRK2 phosphorylates novel tau epitopes and promotes tauopathyHyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filamentsIs L-methionine a trigger factor for Alzheimer's-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type miceComparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's diseaseDown-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's diseaseRegional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementiaTau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tauActivation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrilsSerum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tauTau-mediated synaptic damage in Alzheimer's diseaseAmyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease.ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathyFibrillogenesis of tau: insights from tau missense mutations in FTDP-17.Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits.Protein kinase A phosphorylation of tau-serine 214 reorganizes microtubules and disrupts the endothelial cell barrierThe cytoskeleton in neurodegenerative diseases.Genetic modifiers of tauopathy in Drosophila.Functions of bifans in context of multiple regulatory motifs in signaling networksTyrosine nitration within the proline-rich region of Tau in Alzheimer's diseasePseudomonas aeruginosa exotoxin Y-mediated tau hyperphosphorylation impairs microtubule assembly in pulmonary microvascular endothelial cells.Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)Protein kinase A rescues microtubule affinity-regulating kinase 2-induced microtubule instability and neurite disruption by phosphorylating serine 409.Inflammation induced by infection potentiates tau pathological features in transgenic mice.Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibersE46K human alpha-synuclein transgenic mice develop Lewy-like and tau pathology associated with age-dependent, detrimental motor impairmentNon-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy.Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation.Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice.tau kinases in the rat heat shock model: possible implications for Alzheimer disease.Activating Akt and the brain's resources to drive cellular survival and prevent inflammatory injuryTau phosphorylation sites work in concert to promote neurotoxicity in vivo.Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.Employing new cellular therapeutic targets for Alzheimer's disease: a change for the better?Sensitive quantitative assays for tau and phospho-tau in transgenic mouse modelsCo-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomesDissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model
P2860
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P2860
Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filament-like conformation
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Sequential phosphorylation of ...... cal-filament-like conformation
@ast
Sequential phosphorylation of ...... cal-filament-like conformation
@en
Sequential phosphorylation of ...... cal-filament-like conformation
@nl
type
label
Sequential phosphorylation of ...... cal-filament-like conformation
@ast
Sequential phosphorylation of ...... cal-filament-like conformation
@en
Sequential phosphorylation of ...... cal-filament-like conformation
@nl
prefLabel
Sequential phosphorylation of ...... cal-filament-like conformation
@ast
Sequential phosphorylation of ...... cal-filament-like conformation
@en
Sequential phosphorylation of ...... cal-filament-like conformation
@nl
P2093
P921
P3181
P1433
P1476
Sequential phosphorylation of ...... cal-filament-like conformation
@en
P2093
E Mandelkow
Q Zheng-Fischhöfer
R Godemann
S Illenberger
P304
P3181
P356
10.1046/J.1432-1327.1998.2520542.X
P407
P577
1998-03-15T00:00:00Z