20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
about
Protein 61K, encoded by a gene (PRPF31) linked to autosomal dominant retinitis pigmentosa, is required for U4/U6*U5 tri-snRNP formation and pre-mRNA splicing.The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactionsStructural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particlesEvidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammalsThe 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomesPrp8 protein: at the heart of the spliceosomeBase pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo.The human Prp8 protein is a component of both U2- and U12-dependent spliceosomesIdentification of an RNA-dependent ATPase activity in mammalian U5 snRNPsA mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 proteinA novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reactionThe mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosomeA U5 small nuclear ribonucleoprotein particle protein involved only in the second step of pre-mRNA splicing in Saccharomyces cerevisiae.Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2pCommitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39p.Domain analysis of human U5 RNA. Cap trimethylation, protein binding, and spliceosome assemblyA novel 40S multi-snRNP complex isolated from rat liver nucleiThree novel functional variants of human U5 small nuclear RNAAn abundant U6 snRNP found in germ cells and embryos of Xenopus laevis.Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP familyFunctional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing.Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing.Ribonucleoprotein multimers and their functions.Two immunologically related polypeptides of 72/74 kDa specify a novel 70-100S heterogeneous nuclear RNP.The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/U6.U5] tri-snRNP particle.Members of a family of proteins (the RD family) detected by a U1 70K monoclonal antibody are present in spliceosomal complexes.Identification of autoantibodies to RNA polymerase II. Occurrence in systemic sclerosis and association with autoantibodies to RNA polymerases I and IIITEG-1 CD2BP2 regulates stem cell proliferation and sex determination in the C. elegans germ line and physically interacts with the UAF-1 U2AF65 splicing factorMultiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway.Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transportArchitecture of the U5 small nuclear RNASmall nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditionsMammalian U6 small nuclear RNA undergoes 3' end modifications within the spliceosome.A new U6 small nuclear ribonucleoprotein-specific protein conserved between cis- and trans-splicing systems.The PRP4 (RNA4) protein of Saccharomyces cerevisiae is associated with the 5' portion of the U4 small nuclear RNADomain structure of U2 and U4/U6 small nuclear ribonucleoprotein particles from Trypanosoma brucei: identification of trans-spliceosomal specific RNA-protein interactions.The 5' end domain of U2 snRNA is required to establish the interaction of U2 snRNP with U2 auxiliary factor(s) during mammalian spliceosome assembly.
P2860
Q24292373-D29BCA82-85E3-49D2-B6C3-D1AD730F55FDQ24300349-3C23AB40-313A-4291-B5BA-22512FC772ABQ24305386-084D0699-5C8B-4EE3-B1D3-948367EE948EQ24317255-7D45036D-9719-4A08-8819-F63F7B6B7F46Q24530792-C687ED0A-94B5-4409-9000-16E9F7048FA8Q24532589-B23A2216-CAFE-4B0B-90A9-7E351E56FCE4Q24534416-CCD99898-DE74-41DF-BB0A-7D268EEB6983Q24537373-4C06A6A9-60D2-461E-8EFC-F5CE673490ACQ24539237-9D847A6C-53EF-4967-BF11-77C7D80507F4Q24539395-7ABCF950-C553-4E68-AD8F-80D0E4EEF2B8Q24546120-9B900E26-995B-4F20-8084-8C4390E44429Q24558707-702C350F-1475-454D-BD03-2D306795F5E9Q24594778-37ABC362-534C-4A00-AE4A-FBAD827B7FF4Q24603409-47E8D887-7C56-4C08-909E-224D9C544F0EQ27930011-97E5EAE2-3039-4AF5-BD62-97F215530FC5Q27932768-769C20F4-9526-49E9-8821-847796C20A8CQ27935715-2BE7403D-67E3-4D19-B37A-C91CA7D40276Q27938809-68427173-7D32-4A4E-B231-031107849EBAQ28284343-3E60E99A-FAA0-45C3-BBB1-2ED158AB4919Q28569746-F67334DB-DC21-45E0-9DEF-8E3B76C5907BQ28776179-5F5B7FAF-64C5-416F-B0C8-DC0E1AAD18CAQ33590688-FD297768-E9A4-41E9-85F2-DB3F8B77D4C2Q33838188-867DB762-32B8-42D2-8124-C0C43D689F78Q33888130-F8E787F5-B97D-46DA-86DF-706CC0C8BB62Q33919386-1E48678E-D872-4624-9B5E-485672CDBC62Q34130110-F1BC3CB7-7C1B-4323-92F3-B5424FBD0F3CQ34763131-F020EAFE-8FBD-422B-AF24-6C267820F2CDQ34767752-1F266FEF-5E7A-44FC-832B-6B7224A26DE9Q34776208-DD170B31-01A6-45F5-A7E2-EBBF6298E654Q35611011-DC3C01BF-289B-48E9-92EC-D26515329054Q36304336-AA727AAB-826B-4DEF-937B-990474FF7D72Q36529139-78B8659B-1364-430F-8570-BC492DFBE3E2Q36529688-FBBE9CC8-8407-478A-B4ED-0CD1685297AEQ36649048-F50D582B-EDC7-4A08-9162-AEEF4EE5C2FCQ36659057-F667B157-EC1A-43D9-9768-E99E490C288AQ36676114-88D6525D-B9B4-44C3-94DC-E1173FA8B876Q36688388-29F04F4B-D640-4044-9B51-84E24F43900CQ36722158-8D69034C-EFF2-4611-BAB6-207D6B5F0197Q38330852-6239688A-B19E-4474-A4E2-609419837F33Q38336469-E282485C-48FD-40C7-8A41-8B6DEF931BA2
P2860
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
description
1989 nî lūn-bûn
@nan
1989 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@ast
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@en
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@nl
type
label
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@ast
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@en
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@nl
prefLabel
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@ast
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@en
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@nl
P2093
P2860
P356
P1476
20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition
@en
P2093
P2860
P304
P356
10.1073/PNAS.86.16.6038
P407
P577
1989-08-01T00:00:00Z