Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism - Test2 - elhamkhani - TriplyDB

Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

http://www.wikidata.org/entity/Q24620573

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Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder On the Role of Glutamate in Presynaptic Development: Possible Contributions of Presynaptic NMDA Receptors Following the genes: a framework for animal modeling of psychiatric disorders Cellular and synaptic network defects in autism The molecular basis of cognitive deficits in pervasive developmental disorders Lateral organization of the postsynaptic density Therapeutic approaches for shankopathies Behavioral and Neuroanatomical Phenotypes in Mouse Models of Autism Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism.Genetic aspects of autism spectrum disorders: insights from animal models A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2 Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders Cerebellar and posterior fossa malformations in patients with autism-associated chromosome 22q13 terminal deletion ASD-relevant Animal Models of the Foxp Family of Transcription Factors Knockout of NMDA receptors in parvalbumin interneurons recreates autism-like phenotypes.Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions.Translational animal models of autism and neurodevelopmental disorders.Reduced excitatory neurotransmission and mild autism-relevant phenotypes in adolescent Shank3 null mutant mice Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.Increased gene dosage of Ube3a results in autism traits and decreased glutamate synaptic transmission in mice.Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum.Replicable in vivo physiological and behavioral phenotypes of the Shank3B null mutant mouse model of autism.mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism RECENT DEVELOPMENTS IN NEUROPATHOLOGY OF AUTISM SPECTRUM DISORDERS.Protein interactome reveals converging molecular pathways among autism disorders.Imaging-genetics in autism spectrum disorder: advances, translational impact, and future directions.Fmr1 deficiency promotes age-dependent alterations in the cortical synaptic proteome.Aberrant dendritic excitability: a common pathophysiology in CNS disorders affecting memory?The Notch ligand E3 ligase, Mind Bomb1, regulates glutamate receptor localization in Drosophila.Social, communication, and cortical structural impairments in Epac2-deficient mice.Synaptic plasticity in mouse models of autism spectrum disorders.Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner Environmental factors in autism.Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

http://www.wikidata.org/entity/Q24620573

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011年の論文

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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J.CELL.2011.03.052

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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

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Alena Savonenko

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Bo Xiao

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Craig M Powell

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David J Linden

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Dehua Wang

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Deidre Lee

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Haley E Speed

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Jia-Hua Hu

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Jian Cheng Tu

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Joo Min Park

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P2860

Autism: many genes, common pathways?

Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia.

Strong association of de novo copy number mutations with autism

The postsynaptic density proteins Homer and Shank form a polymeric network structure

Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited

Contribution of SHANK3 mutations to autism spectrum disorder

Structural variation of chromosomes in autism spectrum disorder

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