Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. - Test2 - elhamkhani - TriplyDB

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

http://www.wikidata.org/entity/Q27851485

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Pediatric medulloblastoma - update on molecular classification driving targeted therapies Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation.Pharmacokinetics of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors: the role of alpha-1-acid glycoprotein binding Molecular subgroups of medulloblastoma: the current consensus Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal Medulloblastoma stem cells: Promising targets in medulloblastoma therapy Advances in targeted and immunobased therapies for colorectal cancer in the genomic era Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Aberrant GLI1 Activation in DNA Damage Response, Carcinogenesis and Chemoresistance Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors Targeting the Hedgehog Pathway in Pediatric Medulloblastoma The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling Vismodegib hedgehog-signaling inhibition and treatment of basal cell carcinomas as well as keratocystic odontogenic tumors in Gorlin syndrome The Role of Hedgehog Signaling in Tumor Induced Bone Disease Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis In vivo models of brain tumors: roles of genetically engineered mouse models in understanding tumor biology and use in preclinical studies Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Hedgehog signaling pathway in ovarian cancer Sonic Hedgehog in pancreatic cancer: from bench to bedside, then back to the bench Basal cell carcinoma - molecular biology and potential new therapies Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma Ubiquitination and deubiquitination of REST and its roles in cancers Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance Sonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activity Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.Time-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdown CIViC database Identification of Small Molecule Proliferating Cell Nuclear Antigen (PCNA) Inhibitor That Disrupts Interactions with PIP-box Proteins and Inhibits DNA Replication Structure of the human smoothened receptor bound to an antitumour agent Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

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P2860

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

http://www.wikidata.org/entity/Q27851485

description

2009 nî lūn-bûn

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2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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SCIENCE.1179386

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Smoothened mutation confers re ...... inhibitor in medulloblastoma.

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Bruno Alicke

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Charles M Rudin

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Christina P Ahn

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Christine L Hann

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Christopher A Callahan

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Frederic J de Sauvage

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Gerrit J P Dijkgraaf

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J Fernando Bazan

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Jennifer A Low

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Jeremy Stinson

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P2860

First-in-class, first-in-human phase I results of targeted agents: highlights of the 2008 American society of clinical oncology meeting

Activating Smoothened mutations in sporadic basal-cell carcinoma

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Comparative protein modelling by satisfaction of spatial restraints

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification

Altered neural cell fates and medulloblastoma in mouse patched mutants

The structure and function of G-protein-coupled receptors

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma.

G-protein-coupled receptors and cancer.

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572-4

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633640

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10.1126/SCIENCE.1179386

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5952

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326

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Stephen E. Gould

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2009-10-23T00:00:00Z

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26786112

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19726788

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medulloblastoma

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5310713

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