A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions - Test2 - elhamkhani - TriplyDB

A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

http://www.wikidata.org/entity/Q24632492

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Intracellular seeded aggregation of mutant Cu,Zn-superoxide dismutase associated with amyotrophic lateral sclerosis Prion diseases: immunotargets and therapy Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Self-propagation of pathogenic protein aggregates in neurodegenerative diseases Therapeutic and diagnostic challenges for frontotemporal dementia Neurodegenerative diseases: expanding the prion concept Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target Frontotemporal dementia: a bridge between dementia and neuromuscular disease Spreading of pathology in neurodegenerative diseases: a focus on human studies Legal but lethal: functional protein aggregation at the verge of toxicity Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?New insights into in vitro amyloidogenic properties of human serum albumin suggest considerations for therapeutic precautions A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins.Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease.Conserved acidic amino acid residues in a second RNA recognition motif regulate assembly and function of TDP-43.Inhibition of TDP-43 aggregation by nucleic acid binding Targeting RNA binding proteins involved in neurodegeneration.Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins.Self-propagative replication of Aβ oligomers suggests potential transmissibility in Alzheimer disease.Linking RNA Dysfunction and Neurodegeneration in Amyotrophic Lateral Sclerosis.A yeast functional screen predicts new candidate ALS disease genes Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration.Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice.Corruption and spread of pathogenic proteins in neurodegenerative diseases.Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission?Prions and the potential transmissibility of protein misfolding diseases Aberrant assembly of RNA recognition motif 1 links to pathogenic conversion of TAR DNA-binding protein of 43 kDa (TDP-43)Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone.Prion-like propagation of protein aggregation and related therapeutic strategies.Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis.Stages of pTDP-43 pathology in amyotrophic lateral sclerosis.Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapy In vitro prion-like behaviour of TDP-43 in ALS.

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A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions

http://www.wikidata.org/entity/Q24632492

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

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JBC.M111.231209

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Journal of Biological Chemistry

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A seeding reaction recapitulat ...... -binding protein-43 inclusions

@en

P2093

Kumi Kaneko

http://www.w3.org/2001/XMLSchema#string

Nobuyuki Nukina

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Shoji Watanabe

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P2860

Functional amyloid formation within mammalian tissue.

Structural insights into TDP-43 in nucleic-acid binding and domain interactions

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Protein misfolding, functional amyloid, and human disease

Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form.

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration.

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18664-18672

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scholarly article

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1319612

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10.1074/JBC.M111.231209

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21

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286

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Yoshiaki Furukawa

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2011-03-24T00:00:00Z

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21454603

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