Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins - Test2 - elhamkhani - TriplyDB

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

http://www.wikidata.org/entity/Q24633428

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Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3 CHIP controls the sensitivity of transforming growth factor-beta signaling by modulating the basal level of Smad3 through ubiquitin-mediated degradation Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7 Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro The Smads The cilia-regulated proteasome and its role in the development of ciliopathies and cancer Key role for ubiquitin protein modification in TGFβ signal transduction Role of F-box protein betaTrcp1 in mammary gland development and tumorigenesis Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint A design principle underlying the paradoxical roles of E3 ubiquitin ligases The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity.Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner.Oxidative exposure impairs TGF-β pathway via reduction of type II receptor and SMAD3 in human skin fibroblasts Deficient Smad7 expression: a putative molecular defect in scleroderma.Crosstalk between nuclear factor I-C and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue.The emerging role of the COP9 signalosome in cancer.Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD.Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling Smad signalling in the ovary Transforming growth factor-β and the hallmarks of cancer.Two major Smad pathways in TGF-beta superfamily signalling.Ubiquitin-dependent regulation of TGFbeta signaling in cancer A truncated, activin-induced Smad3 isoform acts as a transcriptional repressor of FSHβ expression in mouse pituitary NF-κB induces miR-148a to sustain TGF-β/Smad signaling activation in glioblastoma.TGF-beta signaling in human skeletal and patterning disorders.Proteasome-dependent down-regulation of activated Stat5A in the nucleus.Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer Differentially Expressed Genes and Signature Pathways of Human Prostate Cancer.Ub on the move.Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression.Bridging proteomics and systems biology: what are the roads to be traveled?Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.Conservation and evolutionary divergence in the activity of receptor-regulated smads Cancer-causing mutations in a novel transcription-dependent nuclear export motif of VHL abrogate oxygen-dependent degradation of hypoxia-inducible factor.

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P2860

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

http://www.wikidata.org/entity/Q24633428

description

2001 nî lūn-bûn

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2001 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2001 թվականի մայիսին հրատարակված գիտական հոդված

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2001年の論文

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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Molecular Biology of the Cell

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Ligand-dependent degradation o ...... f ROC1 and associated proteins

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K Miyazono

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K Tanaka

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M Fukuchi

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P2860

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

Identification of a family of human F-box proteins

A family of mammalian F-box proteins

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

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10.1091/MBC.12.5.1431

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5

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12

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11359933

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34595

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