PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
about
The phosphorylation-dependent regulation of mitochondrial proteins in stress responsesParkinson's disease-associated kinase PINK1 regulates Miro protein level and axonal transport of mitochondriaGenetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation updateFunctional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's diseaseThe mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 traffickingPINK1 is recruited to mitochondria with parkin and associates with LC3 in mitophagyParkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavageBiochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradationPhosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signalingPINK1 cleavage at position A103 by the mitochondrial protease PARL.Inactivation of Pink1 gene in vivo sensitizes dopamine-producing neurons to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and can be rescued by autosomal recessive Parkinson disease genes, Parkin or DJ-1A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fissionThe kinase domain of mitochondrial PINK1 faces the cytoplasmThiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in DrosophilaPINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neuronsMutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal deathBAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradationOxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's diseaseLoss of PINK1 attenuates HIF-1α induction by preventing 4E-BP1-dependent switch in protein translation under hypoxiaStructure and Function of Parkin, PINK1, and DJ-1, the Three Musketeers of NeuroprotectionNuclear transport, oxidative stress, and neurodegenerationCombinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancerUsing Proteomics to Understand How Leishmania Parasites Survive inside the Host and Establish InfectionRedox mechanisms in age-related lung fibrosisCross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and DiseaseUbiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatmentBypassing Mechanisms of Mitochondria-Mediated Cancer Stem Cells Resistance to Chemo- and RadiotherapyParkinson's disease proteins: Novel mitochondrial targets for cardioprotectionElectron Transport Disturbances and Neurodegeneration: From Albert Szent-Györgyi's Concept (Szeged) till Novel Approaches to Boost Mitochondrial BioenergeticsEmerging functional cross-talk between the Keap1-Nrf2 system and mitochondriaMitochondrial dysfunction and oxidative stress in Parkinson's diseasePINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrixThe yeast complex I equivalent NADH dehydrogenase rescues pink1 mutantsParkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration.Neuronal responses to stress and injury in C. elegansPINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1
P2860
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P248
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P2860
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
description
2007 nî lūn-bûn
@nan
2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@ast
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en-gb
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@nl
type
label
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@ast
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en-gb
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@nl
prefLabel
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@ast
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en-gb
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@nl
P2860
P50
P921
P3181
P1433
P1476
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
@en
P2093
Julia W Pridgeon
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0050172
P407
P577
2007-07-01T00:00:00Z