about
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stabilityDOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cellsMammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genesA chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage responseThe mechanisms behind the therapeutic activity of BET bromodomain inhibitionBET bromodomain inhibition as a therapeutic strategy to target c-MycFOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1.Global regulation of erythroid gene expression by transcription factor GATA-1SCL and associated proteins distinguish active from repressive GATA transcription factor complexesRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaSelective inhibition of tumor oncogenes by disruption of super-enhancersAcquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5.The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.WRAD: enabler of the SET1-family of H3K4 methyltransferases.MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia.Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation.An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.Acetylation of GATA-1 is required for chromatin occupancy.Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia.Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.C/EBPα: critical at the origin of leukemic transformation.A rationale to target the SWI/SNF complex for cancer therapy.Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus.Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1.A new bump in the epigenetic landscape.Profile of histone lysine methylation across transcribed mammalian chromatin.A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.Low frequency of MLL3 mutations in colorectal carcinoma.Oncogene interference through targeting of chromatin regulators.In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation.Enhancer dysfunction in leukemia.PAF is in the cabal of MLL1-interacting proteins that promote leukemia.Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation
P50
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P50
description
hulumtues
@sq
researcher
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wetenschapper
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հետազոտող
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name
Christopher R. Vakoc
@ast
Christopher R. Vakoc
@en
Christopher R. Vakoc
@es
Christopher R. Vakoc
@nl
Christopher R. Vakoc
@sl
type
label
Christopher R. Vakoc
@ast
Christopher R. Vakoc
@en
Christopher R. Vakoc
@es
Christopher R. Vakoc
@nl
Christopher R. Vakoc
@sl
prefLabel
Christopher R. Vakoc
@ast
Christopher R. Vakoc
@en
Christopher R. Vakoc
@es
Christopher R. Vakoc
@nl
Christopher R. Vakoc
@sl
P106
P1153
8685299800
P21
P31
P496
0000-0002-1158-7180