MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele. - Test2 - elhamkhani - TriplyDB

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

http://www.wikidata.org/entity/Q33694927

about

Proteasome inhibitors evoke latent tumor suppression programs in pro-B MLL leukemias through MLL-AF4 Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Hijacked in cancer: the KMT2 (MLL) family of methyltransferases Potent inhibition of DOT1L as treatment of MLL-fusion leukemia High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction The super elongation complex (SEC) and MLL in development and disease.Targeted Disruption of the Interaction Between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias The rate of spontaneous mutations in human myeloid cells Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia Knockdown of menin affects pre-mRNA processing and promoter fidelity at the interferon-gamma inducible IRF1 gene Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias.Murine models of acute leukemia: important tools in current pediatric leukemia research.Menin/PRMT5/hedgehog signaling: a potential target for the treatment of multiple endocrine neoplasia type 1 tumors.Chromatin modifications as therapeutic targets in MLL-rearranged leukemia.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis PAFc, a key player in MLL-rearranged leukemogenesis.The molecular mechanics of mixed lineage leukemia.Tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex Targeting β-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours.MLL becomes functional through intra-molecular interaction not by proteolytic processing Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Selective targeting of histone methylation Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia DOT1L, the H3K79 methyltransferase, is required for MLL-AF9-mediated leukemogenesis Challenges and opportunities in targeting the menin-MLL interaction.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?ECSASB2 mediates MLL degradation during hematopoietic differentiation Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond The pathogenesis of mixed-lineage leukemia.EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.MLL leukemia induction by genome editing of human CD34+ hematopoietic cells.

P2860

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P2860

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

http://www.wikidata.org/entity/Q33694927

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

@zh-hans

2010年学术文章

@zh-my

2010年学术文章

@zh-sg

2010年學術文章

@yue

name

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

@ast

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

@en

type

label

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

@ast

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

@en

prefLabel

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

@ast

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

@en

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J.CCR.2009.12.034

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P1476

MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele

@en

P2093

Austin T Thiel

http://www.w3.org/2001/XMLSchema#string

Danielle Feather

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Gary A Koretzky

http://www.w3.org/2001/XMLSchema#string

Hui Zhang

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Peter Blessington

http://www.w3.org/2001/XMLSchema#string

Tao Zou

http://www.w3.org/2001/XMLSchema#string

Xianxin Hua

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Xinjiang Wu

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Zuguo Liu

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P2860

Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells

Direct binding of DNA by tumor suppressor menin

Menin associates with FANCD2, a protein involved in repair of DNA damage

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

Global and Hox-specific roles for the MLL1 methyltransferase

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells

hDOT1L links histone methylation to leukemogenesis.

The complex language of chromatin regulation during transcription

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148-159

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10.1016/J.CCR.2009.12.034

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20159607

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