Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis - Test2 - elhamkhani - TriplyDB

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

http://www.wikidata.org/entity/Q24672350

about

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal A novel role for XIAP in copper homeostasis through regulation of MURR1 THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death No death without life: vital functions of apoptotic effectors Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity Upstream regulatory role for XIAP in receptor-mediated apoptosis Proteolytic cleavage of Livin (ML-IAP) in apoptotic melanoma cells potentially mediated by a non-canonical caspase Chemoresistance in human ovarian cancer: the role of apoptotic regulators Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2 Expression of BIRC7 protein and mRNA in non-Hodgkin's lymphoma The tumor suppressor WARTS activates the Omi / HtrA2-dependent pathway of cell death The mitochondrial serine protease HtrA2/Omi: an overview The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9 Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice Network analyses reveal pervasive functional regulation between proteases in the human protease web Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 Focal adhesion kinase and endothelial cell apoptosis.Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells.IAP-IAP complexes required for apoptosis resistance of C. trachomatis-infected cells.HtrA1 sensitizes ovarian cancer cells to cisplatin-induced cytotoxicity by targeting XIAP for degradation.Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction The role of death-associated protein 3 in apoptosis, anoikis and human cancer Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease.Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism.TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).The protein structures that shape caspase activity, specificity, activation and inhibition.Inhibitor of apoptosis proteins: new therapeutic targets in hematological cancer?Caspases: potential targets for regulating cell death.Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1 Death begets failure in the heart.Targeted therapy for epithelial ovarian cancer.Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species.

P2860

Q24294565-59D3EC25-23ED-4F17-9F00-E4CE2003C90E Q24298215-48D58E42-F163-4918-9BEC-07242F9826D0 Q24302274-02BE3845-C8F6-4082-A9EE-0F46E9D31904 Q24318106-C00AE18F-54BE-432A-B464-73C28E8FF0D8 Q24319057-E852A5E0-5D8B-4BC3-B18C-950413040D36 Q24320297-5DE0F5B1-909B-4CDD-843E-AAFF955F1748 Q24547477-73181B6A-389E-4678-A7CA-1E9C4AC7C23F Q24563793-DB44B0C6-77C6-4FC3-B010-C0E9DC6289D8 Q24656141-674A4C84-0D83-438E-89A5-B630E715075B Q24791433-193883B3-2455-465B-B959-9AA2FACC6A5B Q27024426-1DD6E61B-9FFE-4C9F-93E1-C0F8C44635E2 Q28183611-2899D161-9220-4619-B95A-4C7EC09EC6E2 Q28251881-0E4B4870-81C9-4390-8815-FA3A6A3E8782 Q28260835-ED7E120C-9840-4943-AA54-97223FB35D2C Q28263602-ED5B1FCC-17C0-4593-A377-910381E29C94 Q28289960-F34F3B54-4AE5-4048-8ACC-A289C6D0DD1D Q28507648-D86B3CC1-611C-4134-8757-5DF88BFFCCCD Q28539127-BCD546D5-D852-46F5-9389-F021AB2B679B Q28752238-81FE5DFA-08B1-4273-88DC-D842A8D44FEA Q29616161-8B7C346E-9549-4179-A502-1E377592F683 Q30459602-7D26552D-8702-47E8-9AAD-E55A1A098CFE Q33232619-136AA761-07E4-4C06-8204-5C7F5F1FBD15 Q33261810-C37FFBA5-640C-4F09-BFAE-DC59423E1B12 Q33841141-EA73BF82-4A01-475C-84FC-8F2C913451D1 Q33917799-E4648BD6-BD53-418F-9047-8A6D2581E20D Q34043792-C3017981-3EAD-41C5-83F7-91F81043503D Q34132152-35285DEB-11C4-495B-8D60-145CDAB9DF66 Q34234115-A02386F5-74E6-4CAC-A082-CC9A4E6AE496 Q34315407-BAE09A5C-94BF-48CD-960B-D38DB3B6E8B6 Q34602140-C17333B9-62AD-438C-A80F-D4538B0607B0 Q35111028-F7BFCF5A-84A6-411F-BEBA-2A701BAFA315 Q35902423-FAF7DB55-34CD-4B31-A037-1188896485CA Q35905166-1E844CAA-DCCA-41E4-B433-F9E6D6ADE084 Q35985520-86068DA4-BCDA-48E8-8BBC-B2D91441EC4B Q36044833-8CF0FF7C-EA2A-4C4C-B282-850CE09FB50F Q36070078-D8D730BE-41FF-4424-AA66-7A4E5C0A7546 Q36158708-C7CD214D-5F17-4EBF-B1E5-C20D2A8D80BD Q36384570-DF2E56DB-ADE1-4FB0-9D48-8FBADECD7E50 Q36481187-A09D0050-8607-4FF0-9992-DDB0D32575FB Q36582810-74B7E796-5C9B-4AED-BD9A-DB06A846062A

P2860

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

http://www.wikidata.org/entity/Q24672350

description

2003 nî lūn-bûn

@nan

2003 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@ast

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@en

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@nl

type

label

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@ast

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@en

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@nl

prefLabel

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@ast

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@en

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@nl

P1433

Q24672350-1A6765BD-0BCF-4AD3-A141-72DB3CC39EDD

P1476

Q24672350-DD4003B6-5EFA-4A33-B841-D1D01E0C3362

P2093

Q24672350-24C77129-D988-4894-9533-C76B0B7BAB9B

Q24672350-380F6BC6-3F77-4012-A30F-1A5299C70D35

Q24672350-475B67DC-3548-4695-8B70-A458840A5604

Q24672350-D1F72377-9B4C-49B8-B47D-6631CAFC3A1A

Q24672350-F7024F75-8271-41F2-9385-B37595464E16

P2860

Q24672350-0AA9CDB9-A909-4BB4-A88C-208C524E6764

Q24672350-13EEFD9A-436B-425F-9878-B11B00393556

Q24672350-1E1BDA91-9DFF-4234-8DBA-75D2CE28D012

Q24672350-2C0BFE78-00F1-4F74-A1FE-80EF9D277950

Q24672350-3157116B-AEA6-4D7D-866F-8EBF09A110BA

Q24672350-39304AA0-2ADA-4020-8DDF-2549603A206C

Q24672350-42BC0852-A81E-4C0B-86C1-CD095A457C7C

Q24672350-496FC057-381D-49E4-A063-3AB14E7FB893

Q24672350-49DCFCF2-7517-4045-94BE-BCC041EAEB87

Q24672350-4A3310DF-7D64-4A58-AE53-8D4306C12BFD

P304

Q24672350-62645870-A93E-4427-8186-103D8709AF6D

P31

Q24672350-090D118B-6166-49C3-8C12-D3D5B7DB07F9

P3181

Q24672350-D22AAFE4-3C7A-4626-9675-26751612F7C0

P356

Q24672350-D945D81B-96EF-48EA-AC44-493257A1F10A

P407

Q24672350-C1709A74-F421-4C1C-87AB-0C40BE7F0C91

P433

Q24672350-A62DF321-0298-47CD-B1DD-3ED3810F7A82

P478

Q24672350-7FE415E4-E457-4C6A-A5B0-DEE7F461DA7F

P577

Q24672350-0D5AA682-681A-4995-A1D1-236A5C3491A7

P5875

Q24672350-A546799A-BF26-4571-BD24-68FB5EBCAC3B

P698

Q24672350-A1FD751D-4B95-4599-8DED-C78F856344E2

P921

Q24672350-76DC4B90-3F1A-48E0-8451-9A20D2EBB3BD

P932

Q24672350-B27640BC-8EF1-4DC2-8BF7-7AF5ED633CCF

P3181

P356

P1433

Genes & Development

P1476

Omi/HtrA2 catalytic cleavage o ...... caspase activity in apoptosis

@en

P2093

Chunying Du

http://www.w3.org/2001/XMLSchema#string

Jinyu Ren

http://www.w3.org/2001/XMLSchema#string

Michelle L Newton

http://www.w3.org/2001/XMLSchema#string

Qi-Heng Yang

http://www.w3.org/2001/XMLSchema#string

Robin Church-Hajduk

http://www.w3.org/2001/XMLSchema#string

P2860

Control of apoptosis and mitotic spindle checkpoint by survivin

Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia

Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

X-linked IAP is a direct inhibitor of cell-death proteases

Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs.

The N-end rule: functions, mysteries, uses

P304

1487-96

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

4855374

http://www.w3.org/2001/XMLSchema#string

P356

10.1101/GAD.1097903

http://www.w3.org/2001/XMLSchema#string

P407

P433

12

http://www.w3.org/2001/XMLSchema#string

P478

17

http://www.w3.org/2001/XMLSchema#string

P577

2003-06-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

10701071

http://www.w3.org/2001/XMLSchema#string

P698

12815069

http://www.w3.org/2001/XMLSchema#string

P921

apoptotic process

P932

196079

http://www.w3.org/2001/XMLSchema#string