Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases - Test2 - elhamkhani - TriplyDB

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

http://www.wikidata.org/entity/Q24294565

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ARTS and Siah collaborate in a pathway for XIAP degradation c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation API2-MALT1 oncoprotein promotes lymphomagenesis via unique program of substrate ubiquitination and proteolysis Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation Small-molecule SMAC mimetics as new cancer therapeutics XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization Crystal Structure of the BIR1 Domain of XIAP in Two Crystal Forms Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination The structure of XIAP BIR2: understanding the selectivity of the BIR domains Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions p42MAPK-mediated phosphorylation of xEIAP/XLX in Xenopus cytostatic factor-arrested egg extracts.The mechanism of peptide-binding specificity of IAP BIR domains.A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins.Oncogenic activation of NF-kappaB.Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.Identification of F-box only protein 7 as a negative regulator of NF-kappaB signalling.Inhibitor of Apoptosis (IAP) proteins as drug targets for the treatment of cancer cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand Cyclopeptide Smac mimetics as antagonists of IAP proteins.Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1).Characterization of Potent SMAC Mimetics that Sensitize Cancer Cells to TNF Family-Induced Apoptosis Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Splice variants of mIAP1 have an enhanced ability to inhibit apoptosis Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.Agonist antibodies to TNFR molecules that costimulate T and NK cells Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1 Lipid-conjugated Smac analogues.Inhibitor of apoptosis proteins as intracellular signaling intermediates.Regulation of NF-κB by the CARD proteins The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis.A novel role for RIP1 kinase in mediating TNFα production.A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways.TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation IAPs: what's in a name?

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P2860

Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases

http://www.wikidata.org/entity/Q24294565

description

2006 nî lūn-bûn

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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2006 թվականի հունվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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P1433

Journal of Biological Chemistry

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Distinct BIR domains of cIAP1 ...... hondrial activator of caspases

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P2093

John C Reed

http://www.w3.org/2001/XMLSchema#string

Kate Welsh

http://www.w3.org/2001/XMLSchema#string

Summanuna H Togo

http://www.w3.org/2001/XMLSchema#string

Temesgen Samuel

http://www.w3.org/2001/XMLSchema#string

Thomas Lober

http://www.w3.org/2001/XMLSchema#string

P2860

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

SWISS-MODEL: An automated protein homology-modeling server

The structural basis for the recognition of diverse receptor sequences by TRAF2

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling

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1080-90

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3575545

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10.1074/JBC.M509381200

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2

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281

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2006-01-13T00:00:00Z

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16282325

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P921

protein ubiquitination