Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation - Test2 - elhamkhani - TriplyDB

Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation

Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation

http://www.wikidata.org/entity/Q24675210

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Anti-proliferative protein Tob negatively regulates CPEB3 target by recruiting Caf1 deadenylase Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth The anti-proliferative activity of BTG/TOB proteins is mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) deadenylase subunits of the Ccr4-not complex Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex Structural basis for the antiproliferative activity of the Tob-hCaf1 complex Quantitative characterization of Tob interactions provides the thermodynamic basis for translation termination-coupled deadenylase regulation Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation Transducer of ERBB2.1 (TOB1) as a Tumor Suppressor: A Mechanistic Perspective Contribution of Orb2A stability in regulated amyloid-like oligomerization of Drosophila Orb2 Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor Identification of the Anti-proliferative protein Tob as a MAPK substrate Differential gene expression in human hepatocellular carcinoma Hep3B cells induced by apoptosis-related gene BNIPL-2 The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition Comparative peptide binding studies of the PABC domains from the ubiquitin-protein isopeptide ligase HYD and poly(A)-binding protein. Implications for HYD function Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis Genetic demonstration of a redundant role of extracellular signal-regulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation Tob1 is a constitutively expressed repressor of liver regeneration The role of antiproliferative gene Tob1 in the immune system.Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program Molecular characterization of Tob1 in muscle development in pigs Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation.Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-κB pathway activation in human myometrial cells Evidence providing new insights into TOB-promoted deadenylation and supporting a link between TOB's deadenylation-enhancing and antiproliferative activities.Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells.Mice lacking a transcriptional corepressor Tob are predisposed to cancer.CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins The role of the TOB1 gene in growth suppression of hepatocellular carcinoma.ERK MAP kinase in G cell cycle progression and cancer.Negative regulators in homeostasis of naïve peripheral T cells.Tob, a member of the APRO family, regulates immunological quiescence and tumor suppression.BTG/TOB factors impact deadenylases.Flipping the switch from g1 to s phase with e3 ubiquitin ligases Identification of MEF2-regulated genes during muscle differentiation.New twist in the regulation of cyclin D1.Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob.Myc/miR-378/TOB2/cyclin D1 functional module regulates oncogenic transformation.The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation.Transducer of erbB2.1 is a potential cellular target of gefitinib in lung cancer therapy.

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Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation

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2002 nî lūn-bûn

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2002 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2002年の論文

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Phosphorylation of three regul ...... oliferation and transformation

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Junko K-Tsuzuku

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Rieko Ajima

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Tadashi Yamamoto

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Takahisa Nakamura

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Toru Suzuki

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Yutaka Yoshida

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P2860

Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1

Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases

The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation

Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.

Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1

Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity

The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

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1356-70

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4004694

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10.1101/GAD.962802

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11

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16

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2002-06-01T00:00:00Z

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11323696

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12050114

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phosphorylation

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186319

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