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Combinatorial biosynthesis of novel antibiotics related to daptomycin

Combinatorial biosynthesis of novel antibiotics related to daptomycin

http://www.wikidata.org/entity/Q24676630

about

Cyclic lipodepsipeptides: a new class of antibacterial agents in the battle against resistant bacteria Structure of a Dinuclear Iron Cluster-Containing β-Hydroxylase Active in Antibiotic Biosynthesis Bacterial genome engineering and synthetic biology: combating pathogens Synthetic biology to access and expand nature's chemical diversity Engineering microbial factories for synthesis of value-added products Imaging mass spectrometry and genome mining via short sequence tagging identified the anti-infective agent arylomycin in Streptomyces roseosporus High-throughput synthesis and screening of cyclic peptide antibiotics.Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes.Synthesis and screening of a cyclic peptide library: discovery of small-molecule ligands against human prolactin receptor In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.Genetically engineered lipopeptide antibiotics related to A54145 and daptomycin with improved properties.Metabolic engineering for the production of natural products.Directed evolution of the nonribosomal peptide synthetase AdmK generates new andrimid derivatives in vivo.A retrosynthetic biology approach to metabolic pathway design for therapeutic production Analysis of the linker region joining the adenylation and carrier protein domains of the modular nonribosomal peptide synthetases.The evolving role of chemical synthesis in antibacterial drug discovery.Mapping the limits of substrate specificity of the adenylation domain of TycA.Nonribosomal peptide synthetases involved in the production of medically relevant natural products.A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis Precise cloning and tandem integration of large polyketide biosynthetic gene cluster using Streptomyces artificial chromosome system.Nonribosomal Peptide Synthesis-Principles and Prospects.Novel chemical probes for the investigation of nonribosomal peptide assembly.Reinvigorating natural product combinatorial biosynthesis with synthetic biology Synthetic lipopeptides: a novel class of anti-infectives.Evolution and taxonomic distribution of nonribosomal peptide and polyketide synthases.Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display.How nature morphs peptide scaffolds into antibiotics The structural diversity of acidic lipopeptide antibiotics.Translocation of the thioesterase domain for the redesign of plipastatin synthetase.Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds.Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery Strain improvement in actinomycetes in the postgenomic era.Mupirocin: biosynthesis, special features and applications of an antibiotic from a gram-negative bacterium.Engineering antibiotic production and overcoming bacterial resistance.Metabolic engineering is key to a sustainable chemical industry.Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery.Protein engineering towards natural product synthesis and diversification.Metabolic network modeling and simulation for drug targeting and discovery.Streptomyces temperate bacteriophage integration systems for stable genetic engineering of actinomycetes (and other organisms).Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity.

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Combinatorial biosynthesis of novel antibiotics related to daptomycin

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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Combinatorial biosynthesis of novel antibiotics related to daptomycin

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Combinatorial biosynthesis of novel antibiotics related to daptomycin

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Combinatorial biosynthesis of novel antibiotics related to daptomycin

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Proceedings of the National Academy of Sciences of the United States of America

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Combinatorial biosynthesis of novel antibiotics related to daptomycin

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Daniel Ritz

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Dylan Alexander

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Jian-Qiao Gu

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Kien T Nguyen

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Min Chu

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Paul Brian

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Richard H Baltz

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Vivian Miao

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P2860

Selective interaction between nonribosomal peptide synthetases is facilitated by short communication-mediating domains

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

Enzymology of acyl chain macrocyclization in natural product biosynthesis.

Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus.

The lipopeptide antibiotic A54145 biosynthetic gene cluster from Streptomyces fradiae.

Nonribosomal peptides: from genes to products.

Harnessing the potential of communication-mediating domains for the biocombinatorial synthesis of nonribosomal peptides.

The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections.

Biosynthesis of nonribosomal peptides1.

Daptomycin biosynthesis in Streptomyces roseosporus: cloning and analysis of the gene cluster and revision of peptide stereochemistry.

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