Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles - Test2 - elhamkhani - TriplyDB

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

http://www.wikidata.org/entity/Q24681394

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells Depletion of IK causes mitotic arrest through aberrant regulation of mitotic kinases and phosphatases beta-Catenin is a Nek2 substrate involved in centrosome separation.Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C Rootletin forms centriole-associated filaments and functions in centrosome cohesion Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.Structure and regulation of the human Nek2 centrosomal kinase Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: SAR and Structural Characterization Centrosome - a promising anti-cancer target Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks CDK5RAP2 regulates centriole engagement and cohesion in mice Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells.Loss of Nek11 Prevents G2/M Arrest and Promotes Cell Death in HCT116 Colorectal Cancer Cells Exposed to Therapeutic DNA Damaging Agents The bornavirus-derived human protein EBLN1 promotes efficient cell cycle transit, microtubule organisation and genome stability The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation.ASAP, a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis Nek2 phosphorylates and stabilizes β-catenin at mitotic centrosomes downstream of Plk1.Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.Characterization of a poplar NIMA-related kinase PNek1 and its potential role in meristematic activity.Potential link between the NIMA mitotic kinase and nuclear membrane fission during mitotic exit in Aspergillus nidulans.Dimerization of CPAP orchestrates centrosome cohesion plasticity.The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis Multisite phosphorylation of C-Nap1 releases it from Cep135 to trigger centrosome disjunction Abnormal expression of Nek2 in pancreatic ductal adenocarcinoma: a novel marker for prognosis Coordinate regulation of the mother centriole component nlp by nek2 and plk1 protein kinases.Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms.SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton Auditory late effects of childhood cancer therapy: a report from the Children's Oncology Group Centrosome dynamics as a source of chromosomal instability The centrosome and its duplication cycle Role of NEK2A in human cancer and its therapeutic potentials.

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Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles

http://www.wikidata.org/entity/Q24681394

description

2003 nî lūn-bûn

@nan

2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2003 թվականի հուլիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

@ast

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

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Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

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type

label

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

@ast

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

@en

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

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prefLabel

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

@ast

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

@en

Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

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MBC.E03-02-0108

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Molecular Biology of the Cell

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Nek2A kinase stimulates centro ...... on of bipolar mitotic spindles

@en

P2093

Alison J Faragher

http://www.w3.org/2001/XMLSchema#string

Andrew M Fry

http://www.w3.org/2001/XMLSchema#string

P2860

NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1

The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion

The mechanism regulating the dissociation of the centrosomal protein C-Nap1 from mitotic spindle poles

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators.

Alternative splice variants of the human centrosome kinase Nek2 exhibit distinct patterns of expression in mitosis

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function

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2876-89

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scholarly article

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2980085

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10.1091/MBC.E03-02-0108

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7

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14

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2003-07-01T00:00:00Z

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12857871

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165683

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