Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function - Test2 - elhamkhani - TriplyDB

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

http://www.wikidata.org/entity/Q24682108

about

Human single-stranded DNA binding proteins are essential for maintaining genomic stability Cdc7-Dbf4 and the human S checkpoint response to UVC The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement The Mcm2-7 replicative helicase: a promising chemotherapeutic target Timeless links replication termination to mitotic kinase activation Differences in the DNA replication of unicellular eukaryotes and metazoans: known unknowns The Implications of Multiple Circadian Clock Origins The Causes and Consequences of Topological Stress during DNA Replication Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathway Human Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesion Emerging models for the molecular basis of mammalian circadian timing Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1 Timeless preserves telomere length by promoting efficient DNA replication through human telomeres Contribution of sleep to the repair of neuronal DNA double-strand breaks: evidence from flies and mice.SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.New insights into checkpoint kinase 1 in the DNA damage response signaling network.Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.Sister acts: coordinating DNA replication and cohesion establishment.Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complex Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts The fork and the kinase: a DNA replication tale from a CHK1 perspective.Architecture and ssDNA interaction of the Timeless-Tipin-RPA complex.The Human RNA Polymerase I Transcription Terminator Complex Acts as a Replication Fork Barrier That Coordinates the Progress of Replication with rRNA Transcription Activity.Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in mice.Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.A comparative proteomic study identified LRPPRC and MCM7 as putative actors in imatinib mesylate cross-resistance in Lucena cell line.And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress Replication Protein A (RPA) deficiency activates the Fanconi anemia DNA repair pathway.Plx1 is required for chromosomal DNA replication under stressful conditions Chk1 and Claspin potentiate PCNA ubiquitination.Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.

P2860

Q21263027-D79F3268-2CF4-4254-ABD3-AB782B70C321 Q24672815-9DB8B37E-E6AC-4ABA-A170-8C899149F17E Q24683336-34F8C8A8-8E66-40E8-BCA5-412FCBA2AEC4 Q26861045-EC22EF61-0675-4F6B-9178-1694D9210263 Q27342850-6AF60566-C80A-4DA6-8239-F42A19C732A9 Q27694684-6172E908-19F4-4A97-A12F-F6ECD9CDEA0D Q27909963-449CA33B-CC00-4457-BBAC-CB1DD8FF9D06 Q28077125-5B17A806-503E-4B15-8268-DA5F6555DCF4 Q28114770-82049B8C-BD6E-4942-ABD1-81CEE755DC97 Q28118451-A8675465-7CF5-4B8B-950F-DA84C6980033 Q28249506-5E72DF13-1A89-4514-BBD3-E6064353E243 Q28506381-57076941-20F1-4E7B-8E41-14F2B21571B2 Q29041627-66E575A7-24BF-4A3C-9015-92A49D5FD693 Q30828167-6577D7E9-716C-404C-89F2-71D7DF4DE4F2 Q31171264-611984CD-B624-4A84-BD17-5B5B8195EA07 Q33474752-A1092ED2-133C-4349-B580-A6C744EFE526 Q33533337-8919C462-8EBE-4DBD-8F2B-B0AE98BE5B36 Q33541382-D3B52800-CB95-421A-ADCD-8A14916F5113 Q33661490-CBA7A0E8-29D4-47E9-B133-F8EA6186E536 Q33725551-72685083-5AC2-4F7E-BE06-86F96E826B62 Q34129155-2E68CBF5-1909-4041-85A2-140CCB322A65 Q34406008-FDA58167-C596-4AEF-ADAF-8779B36399B9 Q34411870-DA354F0B-5293-4961-A81C-48E764104F94 Q34561912-97F4EF97-5891-43C8-BBCB-A085CEF83C64 Q35034362-DB6A4CC4-0919-4F07-946C-1087479E7E7B Q35079332-E8EC9941-A1F0-4A2F-984E-2688E10A3299 Q35205026-B6B46FB5-E12A-4250-A955-0D366D27E1CC Q35369529-CCFB7877-25D5-4172-B7E8-F1E22DB2F8C4 Q35516592-C2D0AAE2-4FF7-474B-B1E8-4E30887A326A Q35962436-639519B8-3022-4DE9-B331-0040E37815BF Q35987300-ABCE2FCA-EC10-4E1B-93DD-81E7A94B310B Q35989104-FB613836-1265-48C8-9670-6F5D57AAA286 Q35989991-FF8170CD-7115-47FE-B4CD-771A593F39AD Q35991845-5CC561B3-CDE2-40DB-95E0-27098DB72D47 Q36000849-4E957DA4-0088-4624-96E2-86C8EA56F533 Q36072502-2D01E2B0-E832-4E65-BDB3-6741B8BAC021 Q36491053-A79A741B-B473-4D5D-BD57-CA609F8A8FC7 Q36585485-2B6EE58B-CAFB-4F5E-8E64-001C39C3BF29 Q36618648-9FF92F04-08D8-4DE8-A5A6-B7879F38D1BB Q36812407-EEB5162C-D18A-4ED8-87DA-8099AC289700

P2860

Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function

http://www.wikidata.org/entity/Q24682108

description

2006 nî lūn-bûn

@nan

2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年学术文章

@wuu

2006年学术文章

@zh-cn

2006年学术文章

@zh-hans

2006年学术文章

@zh-my

2006年学术文章

@zh-sg

2006年學術文章

@yue

name

Tipin and Timeless form a mutu ...... stance and checkpoint function

@ast

Tipin and Timeless form a mutu ...... stance and checkpoint function

@en

Tipin and Timeless form a mutu ...... stance and checkpoint function

@nl

type

label

Tipin and Timeless form a mutu ...... stance and checkpoint function

@ast

Tipin and Timeless form a mutu ...... stance and checkpoint function

@en

Tipin and Timeless form a mutu ...... stance and checkpoint function

@nl

prefLabel

Tipin and Timeless form a mutu ...... stance and checkpoint function

@ast

Tipin and Timeless form a mutu ...... stance and checkpoint function

@en

Tipin and Timeless form a mutu ...... stance and checkpoint function

@nl

P1433

Q24682108-AD974A4C-17BF-432E-8C4E-F6EC6E73819A

P1476

Q24682108-54FA2820-EC19-4EFB-9E81-9E7CA4489079

P2093

Q24682108-3A5DAF83-8562-46BA-A081-1C4AAEC41E1E

P2860

Q24682108-08450429-7746-44FC-BB6A-E0AA6914AFC9

Q24682108-29DB52CC-00E6-45DC-AD08-7DCA96651B8E

Q24682108-2DE0A25C-05E7-4B36-92FD-C60DA39036AE

Q24682108-2E6E44B7-FA66-4B12-8DD1-8C5B274777F2

Q24682108-30B1B4CF-E100-4292-A4D8-22EB776BDBD4

Q24682108-30BBA9C5-85FC-4A1B-A3C9-C5D73219CE06

Q24682108-320E0C77-4610-4000-9809-462C0B9C7548

Q24682108-38D847DB-5196-4031-BFDC-C1A5298DCC64

Q24682108-453D0330-F663-4AF3-8F6F-5636B86F6257

Q24682108-499869EA-3216-4548-913E-6C0712C492CD

P304

Q24682108-F3C7ECD1-0324-4F0E-99B1-273792DDE123

P31

Q24682108-311F01BB-0073-4CCB-BA9C-64F8999137E2

P3181

Q24682108-7FAE7E96-02C3-4628-9017-E7481EC05FCA

P356

Q24682108-B4A10C70-796B-4F6D-96A7-3A9629898E0C

P407

Q24682108-ACA4E517-782E-48A0-AC25-8922C50419A9

P433

Q24682108-6A073C91-AFC6-44FB-AC78-89DEAC994890

P478

Q24682108-C1AB4263-A5F3-46B0-9214-ECEF42110EA3

P50

Q24682108-D4E57F16-C067-4557-805B-11CA98E3260F

P577

Q24682108-14BAA3F8-6F0B-4009-8754-1A1EAF49350E

P5875

Q24682108-3F24F245-80BE-4414-B1B5-C4BAF833E9A0

P698

Q24682108-1ECDE250-F3DB-4E7E-AE9A-C0DE425DE2F8

P932

Q24682108-80001559-340A-46C5-A05E-E0E0D8E7F61E

P3181

P356

PNAS.0609251103

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Tipin and Timeless form a mutu ...... stance and checkpoint function

@en

P2093

Danny M Chou

http://www.w3.org/2001/XMLSchema#string

P2860

Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription

Identification of the mammalian homologues of the Drosophila timeless gene, Timeless1

Coupling of human circadian and cell cycles by the timeless protein.

Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

Megabase chromatin domains involved in DNA double-strand breaks in vivo

A comprehensive two-hybrid analysis to explore the yeast protein interactome

Identification of protein complexes required for efficient sister chromatid cohesion.

Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex.

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks.

P304

18143-7

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2600146

http://www.w3.org/2001/XMLSchema#string

P356

10.1073/PNAS.0609251103

http://www.w3.org/2001/XMLSchema#string

P407

P433

48

http://www.w3.org/2001/XMLSchema#string

P478

103

http://www.w3.org/2001/XMLSchema#string

P50

Stephen Elledge

P577

2006-11-28T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

6680872

http://www.w3.org/2001/XMLSchema#string

P698

17116885

http://www.w3.org/2001/XMLSchema#string

P932

1654129

http://www.w3.org/2001/XMLSchema#string