Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
about
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin functionProteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stressCharacterization of functional domains in human ClaspinClaspin promotes normal replication fork rates in human cellsUSP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of ClaspinCommon mechanisms of PIKK regulationThe ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcriptionTipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint functionThe human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacementModulation of DNA damage and repair pathways by human tumour virusesTopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive HematopoiesisDNA damage control: regulation and functions of checkpoint kinase 1Roles of Chk1 in cell biology and cancer therapyATR: an essential regulator of genome integrityFunction of a conserved checkpoint recruitment domain in ATRIP proteins.Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.ATR activation and replication fork restart are defective in FANCM-deficient cells.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poisonAtaxia telangiectasia mutated- and Rad3-related kinase drives both the early and the late DNA-damage response to the monofunctional antitumour alkylator S23906.Requirement of MTA1 in ATR-mediated DNA damage checkpoint function.ATR autophosphorylation as a molecular switch for checkpoint activation.Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradationDynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activityIKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastasesThe RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stallingS-phase sensing of DNA-protein crosslinks triggers TopBP1-independent ATR activation and p53-mediated cell death by formaldehyde.TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cellsHERC2-USP20 axis regulates DNA damage checkpoint through Claspin.Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice.Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling.Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress
P2860
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P2860
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
description
2006 nî lūn-bûn
@nan
2006 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@ast
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@en
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@nl
type
label
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@ast
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@en
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@nl
prefLabel
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@ast
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@en
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@nl
P2860
P50
P356
P1476
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
@en
P2093
Niels Mailand
Shizhou Liu
P2860
P304
P356
10.1128/MCB.00492-06
P407
P577
2006-08-01T00:00:00Z