Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists - Test2 - elhamkhani - TriplyDB

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

http://www.wikidata.org/entity/Q24794838

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NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.Distinct roles of PTCH2 splice variants in Hedgehog signalling A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened Agonizing hedgehog.Roughing up Smoothened: chemical modulators of hedgehog signaling The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway Cytological profiling: providing more haystacks for chemists' needles.Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Hedgehog signaling pathway in ovarian cancer Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Structural basis of Smoothened regulation by its extracellular domains Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model Functional characterization of putative cilia genes by high-content analysis Novel Acylguanidine Derivatives Targeting Smoothened Induce Antiproliferative and Pro-Apoptotic Effects in Chronic Myeloid Leukemia Cells Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus Rer1p maintains ciliary length and signaling by regulating γ-secretase activity and Foxj1a levels.The use of mouse models to understand and improve cognitive deficits in Down syndrome.Stem cell biology and drug discovery.Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.Common activation of canonical Wnt signaling in pancreatic adenocarcinoma.Small molecules in stem cell self-renewal and differentiation.Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries.Solving the puzzle of Parkinson's disease using induced pluripotent stem cells.Converse conformational control of smoothened activity by structurally related small molecules.Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.Chemical genetic screening in the zebrafish embryo.Hedgehog agonist therapy corrects structural and cognitive deficits in a Down syndrome mouse model

P2860

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P2860

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

http://www.wikidata.org/entity/Q24794838

description

2002 nî lūn-bûn

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2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Small-molecule modulators of H ...... hened agonists and antagonists

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Small-molecule modulators of H ...... hened agonists and antagonists

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Small-molecule modulators of H ...... hened agonists and antagonists

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Small-molecule modulators of H ...... hened agonists and antagonists

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Small-molecule modulators of H ...... hened agonists and antagonists

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Small-molecule modulators of H ...... hened agonists and antagonists

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David Bumcrot

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Frank Y Wang

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Henryk Dudek

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Hynek Wichterle

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Janine Shulok

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Jeffery A Porter

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Maria Frank-Kamenetsky

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Oivin Guicherit

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Simon Jones

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Steve Bottega

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P2860

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro

Activating Smoothened mutations in sporadic basal-cell carcinoma

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Small molecule modulation of Smoothened activity

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Transmembrane molecular pump activity of Niemann-Pick C1 protein

The Hedgehog and Wnt signalling pathways in cancer

Hedgehog signaling in animal development: paradigms and principles

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1043011281

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