Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened - Test2 - elhamkhani - TriplyDB

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

http://www.wikidata.org/entity/Q24682703

about

NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion Inhibition of GLI1 gene activation by Patched1 MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Hedgehog signaling regulates segment formation in the annelid Platynereis A small molecule that binds Hedgehog and blocks its signaling in human cells The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis Sonic hedgehog has a dual effect on the growth of retinal ganglion axons depending on its concentration It's all in your head: new insights into craniofacial development and deformation Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists Roughing up Smoothened: chemical modulators of hedgehog signaling Differential role of Hedgehog signaling in human pancreatic (patho-) physiology: An up to date review Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors Advanced basal cell carcinoma, the hedgehog pathway, and treatment options - role of smoothened inhibitors Hedgehog Cholesterolysis: Specialized Gatekeeper to Oncogenic Signaling The Role of Hedgehog Signaling in Tumor Induced Bone Disease Hedgehog Signaling in the Maintenance of Cancer Stem Cells Holoprosencephaly: signaling interactions between the brain and the face, the environment and the genes, and the phenotypic variability in animal models and humans Hedgehog signaling pathway in ovarian cancer Basal cell carcinoma - molecular biology and potential new therapies Primary cilium and sonic hedgehog signaling during neural tube patterning: role of GPCRs and second messengers Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma Sox2 transcription network acts as a molecular switch to regulate properties of neural stem cells Meis3 is required for neural crest invasion of the gut during zebrafish enteric nervous system development.Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung.In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model The small GTPase Rab29 is a common regulator of immune synapse assembly and ciliogenesis Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

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P2860

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

http://www.wikidata.org/entity/Q24682703

description

2002 nî lūn-bûn

@nan

2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@ast

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@en

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@nl

type

label

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@ast

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@en

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@nl

prefLabel

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@ast

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@en

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@nl

P1433

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Genes & Development

P1476

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

@en

P2093

Jussi Taipale

http://www.w3.org/2001/XMLSchema#string

Michael K Cooper

http://www.w3.org/2001/XMLSchema#string

Philip A Beachy

http://www.w3.org/2001/XMLSchema#string

P2860

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Transmembrane molecular pump activity of Niemann-Pick C1 protein

The Hedgehog and Wnt signalling pathways in cancer

Hedgehog signaling in animal development: paradigms and principles

Patched acts catalytically to suppress the activity of Smoothened

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched

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scholarly article

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1509162

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10.1101/GAD.1025302

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11050257

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12414725

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187469

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