P688
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcriptionPerinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's diseaseCiliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington diseaseHuntingtin is required for mitotic spindle orientation and mammalian neurogenesisα-Synuclein modifies huntingtin aggregation in living cellsOptineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosisDictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylationHuntingtin contains a highly conserved nuclear export signalDevelopment and application of a DNA microarray-based yeast two-hybrid systemHuntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1Huntingtin promotes cell survival by preventing Pak2 cleavagepARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular traffickingHuntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neuronsHuntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 GluedSUMO modification of Huntingtin and Huntington's disease pathologyPhosphorylation of profilin by ROCK1 regulates polyglutamine aggregationHuntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicityPolyglutamine expansion of huntingtin impairs its nuclear exportHuntingtin functions as a scaffold for selective macroautophagyHuman mutant huntingtin disrupts vocal learning in transgenic songbirdsIntrinsically disordered proteins as molecular shieldsHYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activityHuntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease.Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease.siRNA screen identifies QPCT as a druggable target for Huntington's disease.Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity.SERF protein is a direct modifier of amyloid fiber assembly.
P921
Q22254119-9F86173F-0FF2-4EDA-BDF5-6C402E73B81CQ24292381-36B06B91-573A-47C2-A370-47D0653E4FDCQ24292909-036EF899-E6D7-4C0B-9200-EC0F4FDDFC6EQ24294765-D94BE20D-DD8C-4090-B0DD-A0EF596B2E81Q24298430-09CB20C5-8498-47F6-A29C-74AD74C81796Q24300284-C7096C8C-216A-4B42-B33A-F91A6F0B1F23Q24302001-6F0022D3-9BDF-4164-B433-6B992CE0C8A7Q24303895-0876EDE0-4396-42A6-A593-2DD643B69B4CQ24307459-90121033-1C14-4DBB-A7DB-A68E6DACBD31Q24310249-975CC5F0-189B-4203-8549-37B6652FBBFDQ24314724-1E9DF2C2-0104-426C-9437-C1AFBA2946ABQ24316303-98579EE4-A3B4-4A20-B981-CBE1044D9A43Q24317574-EAFA93D8-D7C1-4768-AEE4-84BDFB6838F7Q24323114-0D1F5655-7CA2-4D9E-9B14-6451BC0EECEAQ24324137-11C9A929-E31F-431C-A954-211DEF18B539Q24324878-18FA9BA3-60F4-46F6-B551-21D2527BC496Q24337727-811FA5A3-4ACF-45B4-BE9E-86689C045BADQ24338269-52EBEC8E-8CB1-4481-BE7E-2473C041FBAEQ28118022-790F07A6-8AC4-4C51-AF07-23DED66DED5AQ28118833-277E4370-13AB-48D5-B423-CDBA77A07421Q28910362-B7446E54-8B47-486A-A8DA-EF55D6874007Q28910407-F18ACFAB-8ACA-4CC3-BD3A-20E08ED43B4EQ30480364-8DA66A71-EC11-438B-BFE8-62EEA7F37FFBQ35130191-23580D77-A88E-4CD2-BFDF-C81A5C172214Q36416732-08BDED83-652A-4C73-8EFD-72D60B31022DQ37209664-B7D27472-51F7-487F-BF03-684810B7FCD1Q41810757-974CBD72-2CB9-4D6A-8A7D-95FC0E66B301
P921
description
Gen bzw. Protein, dessen Mutation zu Chorea Huntington führen kann
@de
mammalian protein found in Homo sapiens
@en
menselijk eiwit
@nl
pattedyr-, menneskeprotein
@nn
protein
@id
protein
@sv
proteinë
@sq
protèin
@ace
protéine humaine
@fr
بروتين في الإنسان العاقل
@ar
name
HTT
@cy
Huntingtin
@de
Huntingtin
@en
Huntingtin
@nb
Huntingtin
@nl
Huntingtin
@sv
Huntingtina
@ca
Huntingtina
@it
Huntingtine
@fr
huntingtin
@nn
type
label
HTT
@cy
Huntingtin
@de
Huntingtin
@en
Huntingtin
@nb
Huntingtin
@nl
Huntingtin
@sv
Huntingtina
@ca
Huntingtina
@it
Huntingtine
@fr
huntingtin
@nn
altLabel
HD protein
@en
HTT
@en
HTT
@nn
Hungtingtin
@sv
huntingtin
@en
huntington disease protein
@en
prefLabel
HTT
@cy
Huntingtin
@de
Huntingtin
@en
Huntingtin
@nb
Huntingtin
@nl
Huntingtin
@sv
Huntingtina
@ca
Huntingtina
@it
Huntingtine
@fr
huntingtin
@nn
P361
P638
P680
P681
P682
P352
P6366
P637
P646
P31
P352
P6366
2781427258
P637
P638
P646
P680
P681
P682
P702
P703
P705
ENSP00000347184
ENSP00000425743