Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
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Disruption of Fyn SH3 domain interaction with a proline-rich motif in liver kinase B1 results in activation of AMP-activated protein kinaseMicro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25STRAD pseudokinases regulate axogenesis and LKB1 stabilityMetformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentrationAMP-activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparationRegulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunitMO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinasesFatal congenital heart glycogenosis caused by a recurrent activating R531Q mutation in the gamma 2-subunit of AMP-activated protein kinase (PRKAG2), not by phosphorylase kinase deficiency.Identification of Protor as a novel Rictor-binding component of mTOR complex-2LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1Downregulation of AMP-activated protein kinase by Cidea-mediated ubiquitination and degradation in brown adipose tissueStructure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activationCharacterization of an alternative splice variant of LKB1Signaling by target of rapamycin proteins in cell growth controlRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexInvolvement of Per-Arnt-Sim (PAS) kinase in the stimulation of preproinsulin and pancreatic duodenum homeobox 1 gene expression by glucoseAmino acids as regulators of gene expressionA pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cellsResveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterasesAMP-activated protein kinase, stress responses and cardiovascular diseasesRole of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacksBateman domains and adenosine derivatives form a binding contractThe AMPK signalling pathway coordinates cell growth, autophagy and metabolismThe tuberous sclerosis complexAMPK in the brain: its roles in energy balance and neuroprotectionThe tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressThrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase betaSkeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3Connecting LKB1 and AMPK links metabolism with cancerAt the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulationRegulation and function of AMPK in physiology and diseasesDiabetes mellitus and metformin in hepatocellular carcinomaRegulation of exercise-stimulated glucose uptake in skeletal muscleAdenosine monophosphate-activated protein kinase in diabetic nephropathyAMPK activators: mechanisms of action and physiological activitiesRegulation of AMP-activated protein kinase by natural and synthetic activatorsEnergy disruptors: rising stars in anticancer therapy?Targeting LKB1 in cancer - exposing and exploiting vulnerabilitiesAMPK as a potential anticancer target - friend or foe?
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P2860
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
description
2003 nî lūn-bûn
@nan
2003 թուականին հրատարակուած գիտական յօդուած
@hyw
2003 թվականին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@ast
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en-gb
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@nl
type
label
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@ast
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en-gb
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@nl
prefLabel
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@ast
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en-gb
Complexes between the LKB1 tum ...... tivated protein kinase cascade
@nl
P2093
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Complexes between the LKB1 tum ...... tivated protein kinase cascade
@en
P2093
D Grahame Hardie
Jennifer L Reid
Kirsty J Mustard
Simon A Hawley
Tomi P Mäkelä
P2860
P2888
P3181
P356
10.1186/1475-4924-2-28
P407
P577
2003-01-01T00:00:00Z
P5875
P6179
1015797791