Amino acids and mTORC1: from lysosomes to disease - Test2 - elhamkhani - TriplyDB

Amino acids and mTORC1: from lysosomes to disease

Amino acids and mTORC1: from lysosomes to disease

http://www.wikidata.org/entity/Q27009377

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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 The effects of testosterone deprivation and supplementation on proteasomal and autophagy activity in the skeletal muscle of the male mouse: differential effects on high-androgen responder and low-androgen responder muscle groups The crucial impact of lysosomes in aging and longevity Milk: a postnatal imprinting system stabilizing FoxP3 expression and regulatory T cell differentiation Regulation of the Target of Rapamycin and Other Phosphatidylinositol 3-Kinase-Related Kinases by Membrane Targeting MYC and metabolism on the path to cancer Asparaginase treatment side-effects may be due to genes with homopolymeric Asn codons (Review-Hypothesis)Optimal body weight for health and longevity: bridging basic, clinical, and population research Bolus vs. continuous feeding to optimize anabolism in neonates Wip1 phosphatase: between p53 and MAPK kinases pathways The role of TRPMLs in endolysosomal trafficking and function Role of amino acid transporters in amino acid sensing Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR Role of p62/SQSTM1 in liver physiology and pathogenesis βA3/A1-crystallin: more than a lens protein The lysosome: from waste bag to potential therapeutic target Leucine is a major regulator of muscle protein synthesis in neonates Regulation of mTORC1 by amino acids Nutrient regulation of the mTOR complex 1 signaling pathway Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.SEACing the GAP that nEGOCiates TORC1 activation: evolutionary conservation of Rag GTPase regulation.Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling.p62/SQSTM1 functions as a signaling hub and an autophagy adaptor Sestrin2 is a leucine sensor for the mTORC1 pathway The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1 The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo Effects of Interferons and Viruses on Metabolism Autophagy--A free meal in sickness-associated anorexia Regulation of B Cell Differentiation by Intracellular Membrane-Associated Proteins and microRNAs: Role in the Antibody Response Placental Origins of Chronic Disease.BAX inhibitor-1-associated V-ATPase glycosylation enhances collagen degradation in pulmonary fibrosis.Starved epithelial cells uptake extracellular matrix for survival.Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.Rab1 in cell signaling, cancer and other diseases Lysosomal adaptation: how the lysosome responds to external cues Activity-independent targeting of mTOR to lysosomes in primary osteoclasts

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Amino acids and mTORC1: from lysosomes to disease

http://www.wikidata.org/entity/Q27009377

description

2012 nî lūn-bûn

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2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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name

Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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Amino acids and mTORC1: from lysosomes to disease

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J.MOLMED.2012.05.007

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Trends in Molecular Medicine

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Amino acids and mTORC1: from lysosomes to disease

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P2093

Roberto Zoncu

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P2860

Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B

Structural basis for AMP binding to mammalian AMP-activated protein kinase

Structure of mammalian AMPK and its regulation by ADP

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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524-533

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1681408

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10.1016/J.MOLMED.2012.05.007

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9

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David M Sabatini

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2012-06-28T00:00:00Z

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228100709

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