A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. - Test2 - elhamkhani - TriplyDB

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

http://www.wikidata.org/entity/Q27852958

about

Inhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and Beyond Toward rapamycin analog (rapalog)-based precision cancer therapy Amino acid management in cancer The PI3K/AKT Pathway and Renal Cell Carcinoma The expanding role of mTOR in cancer cell growth and proliferation Deep Blue "Seq": Fishing for Epilepsy Genes.CIViC database Response and acquired resistance to everolimus in anaplastic thyroid cancer Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives mTOR inhibitors in cancer therapy Beyond indigestion: emerging roles for lysosome-based signaling in human disease Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging Computer-aided targeting of the PI3K/Akt/mTOR pathway: toxicity reduction and therapeutic opportunities Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors Renal cell carcinoma.Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.Association of MTOR Mutations With Developmental Brain Disorders, Including Megalencephaly, Focal Cortical Dysplasia, and Pigmentary Mosaicism.Genomic profiling reveals mutational landscape in parathyroid carcinomas Idelalisib sensitivity and mechanisms of disease progression in relapsed TCF3-PBX1 acute lymphoblastic leukemia Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy.Recent progress in the study of the Rheb family GTPases.Novel agents and associated toxicities of inhibitors of the pi3k/Akt/mtor pathway for the treatment of breast cancer Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2.Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.Hemispheric cortical dysplasia secondary to a mosaic somatic mutation in MTOR.Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction on 4E-BP1 dephosphorylation.mTOR coordinates protein synthesis, mitochondrial activity and proliferation.BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer PAT4 levels control amino-acid sensitivity of rapamycin-resistant mTORC1 from the Golgi and affect clinical outcome in colorectal cancer Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model Retrospective Study of Sirolimus and Cyclophosphamide in Patients with Advanced Differentiated Thyroid Cancers.RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes.Next-generation sequencing reveals somatic mutations that confer exceptional response to everolimus.Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.

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A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

http://www.wikidata.org/entity/Q27852958

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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type

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A Diverse Array of Cancer-Asso ...... Predict Rapamycin Sensitivity

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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A diverse array of cancer-asso ...... predict rapamycin sensitivity.

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2159-8290.CD-13-0929

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Cancer Discovery

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A diverse array of cancer-asso ...... predict rapamycin sensitivity

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Andrew H Beck

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Brian C Grabiner

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Kuang Shen

http://www.w3.org/2001/XMLSchema#string

Kıvanc Birsoy

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Sumi Sinha

http://www.w3.org/2001/XMLSchema#string

Valentina Nardi

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P2860

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

International network of cancer genome projects.

Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer

mTOR: from growth signal integration to cancer, diabetes and ageing

mTOR signaling in growth control and disease

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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554-563

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2239824

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10.1158/2159-8290.CD-13-0929

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5

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4

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Richard Possemato

Alexander Jordan

David M Sabatini

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2014-03-14T00:00:00Z

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24631838

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4012430

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