Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
about
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5AIntrinsically unstructured domain 3 of hepatitis C Virus NS5A forms a "fuzzy complex" with VAPB-MSP domain which carries ALS-causing mutationsHepatitis C virus NS5B and host cyclophilin A share a common binding site on NS5AVirologic Tools for HCV Drug Resistance TestingThe yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNAArchitecture and biogenesis of plus-strand RNA virus replication factoriesStructures of hepatitis C virus nonstructural proteins required for replicase assembly and functionAsymmetric binding to NS5A by daclatasvir (BMS-790052) and analogs suggests two novel modes of HCV inhibition.Human Choline Kinase-α Promotes Hepatitis C Virus RNA Replication through Modulation of Membranous Viral Replication Complex FormationIdentification of Hepatitis C Virus NS5A InhibitorsCyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5AThe crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitorsMetabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activityA quantitative high-resolution genetic profile rapidly identifies sequence determinants of hepatitis C viral fitness and drug sensitivityCoordination of Hepatitis C Virus Assembly by Distinct Regulatory Regions in Nonstructural Protein 5AThe Disordered Region of the HCV Protein NS5A: Conformational Dynamics, SH3 Binding, and PhosphorylationHepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interactionApplications of computer-aided approaches in the development of hepatitis C antiviral agents.Common molecular mechanism of the hepatic lesion and the cardiac parasympathetic regulation in chronic hepatitis C infection: a critical role for the muscarinic receptor type 3.Hepatitis C virus nonstructural protein 5A: biochemical characterization of a novel structural class of RNA-binding proteinsSmall molecules targeting hepatitis C virus-encoded NS5A cause subcellular redistribution of their target: insights into compound modes of action.Chemical genetics.Resistance analysis of the hepatitis C virus NS5A inhibitor BMS-790052 in an in vitro replicon system.Expanding the proteome of an RNA virus by phosphorylation of an intrinsically disordered viral protein.All three domains of the hepatitis C virus nonstructural NS5A protein contribute to RNA binding.Discovery of potent hepatitis C virus NS5A inhibitors with dimeric structures.Distinct functions of NS5A in hepatitis C virus RNA replication uncovered by studies with the NS5A inhibitor BMS-790052Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems.Hepatitis C NS5A protein: two drug targets within the same protein with different mechanisms of resistance.Insights into the complexity and functionality of hepatitis C virus NS5A phosphorylation.Genetic history of hepatitis C virus in Venezuela: high diversity and long time of evolution of HCV genotype 2.Hepatitis C virus NS5A inhibitors and drug resistance mutations.Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.The intraviral protein interaction network of hepatitis C virus.Structural and molecular basis of interaction of HCV non-structural protein 5A with human casein kinase 1α and PKR.Resistance patterns associated with HCV NS5A inhibitors provide limited insight into drug binding.Identification of a novel phosphorylation site in hepatitis C virus NS5ADomain 3 of NS5A protein from the hepatitis C virus has intrinsic alpha-helical propensity and is a substrate of cyclophilin A.Daclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.
P2860
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P2860
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@ast
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@en
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@nl
type
label
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@ast
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@en
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@nl
prefLabel
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@ast
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@en
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus
@en
P2093
Ciarán N Cronin
Michael J Hickey
Oleg Brodsky
Peter A Wells
Robert A Love
P2860
P304
P3181
P356
10.1128/JVI.02352-08
P577
2009-05-01T00:00:00Z