Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity
about
The lipid kinase phosphatidylinositol-4 kinase III alpha regulates the phosphorylation status of hepatitis C virus NS5AA host YB-1 ribonucleoprotein complex is hijacked by hepatitis C virus for the control of NS3-dependent particle productionMechanisms of Cellular Membrane Reorganization to Support Hepatitis C Virus ReplicationHepatitis C virus relies on lipoproteins for its life cycleArchitecture and biogenesis of plus-strand RNA virus replication factoriesCuring a viral infection by targeting the host: the example of cyclophilin inhibitorsLipids at the interface of virus-host interactionsPhosphoinositides: tiny lipids with giant impact on cell regulationLipid kinases as therapeutic targets for chronic painThe high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor designElucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approachesPtdIns4P synthesis by PI4KIIIα at the plasma membrane and its impact on plasma membrane identityA role for retromer in hepatitis C virus replicationCinderella story: PI4P goes from precursor to key signaling moleculeRab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replicationNS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains.Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a phosphatidylinositol 4-phosphate-enriched microenvironmentPlasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.Hepatitis C virus life cycle and lipid metabolismDaclatasvir inhibits hepatitis C virus NS5A motility and hyper-accumulation of phosphoinositides.Potent, selective small molecule inhibitors of type III phosphatidylinositol-4-kinase α- but not β-inhibit the phosphatidylinositol signaling cascade and cancer cell proliferation.Cyclophilin and NS5A inhibitors, but not other anti-hepatitis C virus (HCV) agents, preclude HCV-mediated formation of double-membrane-vesicle viral factoriesDetection and manipulation of phosphoinositides.Modulation of the Host Lipid Landscape to Promote RNA Virus Replication: The Picornavirus Encephalomyocarditis Virus Converges on the Pathway Used by Hepatitis C VirusEvaluation of phosphatidylinositol-4-kinase IIIα as a hepatitis C virus drug targetPhosphoinositides in the hepatitis C virus life cycle.Hepatitis C virus-host interactions, replication, and viral assemblyMutations in Encephalomyocarditis Virus 3A Protein Uncouple the Dependency of Genome Replication on Host Factors Phosphatidylinositol 4-Kinase IIIα and Oxysterol-Binding ProteinSHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core proteinHigh-throughput RNA interference screens integrative analysis: Towards a comprehensive understanding of the virus-host interplay.Approaches to hepatitis C treatment and cure using NS5A inhibitorsUnderstanding the hepatitis C virus life cycle paves the way for highly effective therapies.Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.Hepatitis C virus and natural compounds: a new antiviral approach?Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks.The molecular and structural basis of advanced antiviral therapy for hepatitis C virus infection.Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair.Hepatitis C Virus Replication.Hepatitis C Virus Subverts Human Choline Kinase-α To Bridge Phosphatidylinositol-4-Kinase IIIα (PI4KIIIα) and NS5A and Upregulates PI4KIIIα Activation, Thereby Promoting the Translocation of the Ternary Complex to the Endoplasmic Reticulum for Viral
P2860
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P2860
Metabolism of phosphatidylinositol 4-kinase IIIα-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@ast
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@en
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@nl
type
label
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@ast
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@en
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@nl
prefLabel
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@ast
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@en
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@nl
P2093
P2860
P50
P3181
P1433
P1476
Metabolism of phosphatidylinos ...... zoline with antiviral activity
@en
P2093
Annalisa Bianco
Chiara Baruffa
Lorena Donnici
Petra Neddermann
Reinaldo Alvarez
Simone Fenu
Veronica Reghellin
P2860
P304
P3181
P356
10.1371/JOURNAL.PPAT.1002576
P407
P577
2012-03-08T00:00:00Z