Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
about
Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assemblyA crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.PH domain of ELMO functions in trans to regulate Rac activation via Dock180Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cellsStructural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS modelNucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding moduleRational design of small molecule inhibitors targeting RhoA subfamily Rho GTPasesThe 'invisible hand': regulation of RHO GTPases by RHOGDIsGalphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domainThe DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationRegulation of small GTPases by GEFs, GAPs, and GDIsThe Rac1 hypervariable region in targeting and signaling: a tail of many storiesPhosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins.The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidanceHigh resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loopAlternative splicing of Rac1 generates Rac1b, a self-activating GTPaseStructure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residueCrystal structure of the rac activator, Asef, reveals its autoinhibitory mechanismA Catalytic Coiled Coil: Structural Insights into the Activation of the Rab GTPase Sec4p by Sec2pCrystal structure of the Sec4p{middle dot}Sec2p complex in the nucleotide exchanging intermediate stateRelease of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppressionStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav13D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reactionStructural insights into host GTPase isoform selection by a family of bacterial GEF mimicsActivation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensorStructure of the GTPase and GDI domains of FeoB, the ferrous iron transporter of Legionella pneumophilaStructure of Shigella IpgB2 in Complex with Human RhoA: IMPLICATIONS FOR THE MECHANISM OF BACTERIAL GUANINE NUCLEOTIDE EXCHANGE FACTOR MIMICRYThe Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor IntersectinGDP-bound and Nucleotide-free Intermediates of the Guanine Nucleotide Exchange in the Rab5{middle dot}Vps9 SystemStructural and Functional Characterization of the Kindlin-1 Pleckstrin Homology DomainIntermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Protein Catalyzed by Guanine Nucleotide Exchange Factors Rabin8 and GRABDirect metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reactionRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Cancer Stem Cells and Radioresistance: Rho/ROCK Pathway Plea AttentionTiam1 regulates the Wnt/Dvl/Rac1 signaling pathway and the differentiation of midbrain dopaminergic neuronsDock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migrationLeukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoATrp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors
P2860
Q24291439-A097172E-8FDC-4532-BE73-C83F047958F3Q24292431-A7ADFF82-9817-451C-B1B3-7E56B6C335F6Q24299119-A1DA18B4-2FD3-444B-A3D0-23D61A978446Q24299546-6A84E05F-6806-4E60-9B6F-80C7FDCA1E79Q24300730-247388A3-C59D-4461-BEBA-06ED8A256BF9Q24307703-DCEA6BDF-0D4B-4C02-AC1F-8436A2E4F2BCQ24307945-7E380FFB-C915-46C1-BAEF-0B83295CF1D9Q24314777-82578A34-2577-4645-954B-0B0D9D6CF64FQ24597996-56E34BEA-06EE-4C2A-9B7D-49D72C74F5CAQ24606819-86A6ACF3-0819-452A-A8FC-9AE931141E0FQ24658016-D824C5FE-A4C4-493F-A57C-BB012A8F1011Q24675414-45C11954-B46D-49FD-87A5-EA06427ABD38Q26825750-0CBAE87A-71CA-4148-A11C-3C59F5FF94A3Q26864271-D0331A3D-2F88-4CE0-941F-C73E79AD9C2DQ27320795-6DD9088D-1F3E-4F86-A2DB-D214A814440DQ27334152-A1A91FDB-9D5E-47BF-9C18-7E70FFA04F5BQ27639966-8580DC55-71D7-4990-8705-4C3300C33436Q27642578-6AD16389-94AA-4EA0-AB02-8825B653B16DQ27642799-7BC0473C-F6F3-4F73-A577-6D168F5537DDQ27643433-09969568-7625-4204-958A-B2D1E118B7AEQ27643770-663AB97E-AB19-4DB2-A788-F27709C013F5Q27644726-63266CC8-FAFE-4887-B702-5FA615B2B3C2Q27647382-32BE2645-26D0-4242-BBAF-A9CAD221E03DQ27651005-B66CE32D-73F1-48F9-975E-849760DBF209Q27654526-3C11CDF2-098B-4B4A-B5E5-1F6A3371DDE6Q27656575-6A6721F8-017A-453A-B5D4-FCEB534749BBQ27657391-A673D97E-57C2-45C5-AB09-9FA18F05ACF9Q27658791-3EBFF97C-C01C-4BFE-967D-2CF31D86BFFEQ27660409-D3E99C14-F847-4ECF-85FF-1C8467921955Q27662864-F38BA35E-2FE8-47A2-8A1A-7C47245EFC78Q27664432-F8E51501-90C1-4D69-BB01-427352E7B216Q27675000-A26A26EC-8317-424E-972B-2E5E86C06973Q27680081-C600412F-2A6C-42CC-8C5D-72E1ABE77A42Q27684228-24F1FDC9-F2EA-45AB-8D72-4C1DACC58896Q27690752-D3953707-A31E-4D00-9A04-A225010C7C93Q28069232-BFFF9AFD-1530-4099-8ED4-4A6FACF8EECDQ28116790-A3192626-B3E3-4C4F-A862-7FCBDFDFB09CQ28187402-4D603BC7-D442-451B-90AD-07A9F314755BQ28190494-0866CA3D-FF3D-49B7-9424-AF26A8B43AE9Q28191525-2C44D575-A1A9-4035-A3E0-ACD5B9265E93
P2860
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@ast
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@en
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@nl
type
label
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@ast
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@en
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@nl
prefLabel
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@ast
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@en
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@nl
P3181
P356
P1433
P1476
Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
@en
P2093
D K Worthylake
K L Rossman
P2888
P3181
P356
10.1038/35047014
P407
P50
P577
2000-12-07T00:00:00Z
P5875
P6179
1016895952