about
A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFsStructural basis for the selective activation of Rho GTPases by Dbl exchange factorsPH domain of ELMO functions in trans to regulate Rac activation via Dock180Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domainThe DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activationCrystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpAA unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha qStructural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunitsStructural Insights into Fibronectin Type III Domain-mediated SignalingType III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target InteractionRelease of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppressionCrystal structure of the multifunctional Gβ5–RGS9 complexGeneral and Versatile Autoinhibition of PLC IsozymesStructure and Function of Vps15 in the Endosomal G Protein Signaling Pathway ,Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling ComplexAutoinhibition and Phosphorylation-Induced Activation of Phospholipase C-γ IsozymesLeukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoAPhagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMOLoss of phosphatidylinositol 3-phosphate binding by the C-terminal Tiam-1 pleckstrin homology domain prevents in vivo Rac1 activation without affecting membrane targetingMultifunctional roles for the PH domain of Dbs in regulating Rho GTPase activationRole of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteinsThe pleckstrin homology domain of phospholipase C-beta2 as an effector site for Rac.Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins.Structure of Galpha(i1) bound to a GDP-selective peptide provides insight into guanine nucleotide exchangeHigh-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assayThe Pseudomonas syringae effector AvrRpt2 cleaves its C-terminally acylated target, RIN4, from Arabidopsis membranes to block RPM1 activation.High-throughput fluorescence polarization assay for the enzymatic activity of GTPase-activating protein of ADP-ribosylation factor (ARFGAP).Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.Direct activation of human phospholipase C by its well known inhibitor u73122.Direct activation of phospholipase C-epsilon by Rho.Ggamma-like (GGL) domains: new frontiers in G-protein signaling and beta-propeller scaffolding.RhoGEF specificity mutants implicate RhoA as a target for Dbs transforming activity.Small molecule inhibitors of phospholipase C from a novel high-throughput screen.AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thalianaRegulation of phospholipase C isozymes by ras superfamily GTPases.SmgGDS is a guanine nucleotide exchange factor that specifically activates RhoA and RhoC.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
John Sondek
@ast
John Sondek
@en
John Sondek
@es
John Sondek
@nl
John Sondek
@sl
type
label
John Sondek
@ast
John Sondek
@en
John Sondek
@es
John Sondek
@nl
John Sondek
@sl
prefLabel
John Sondek
@ast
John Sondek
@en
John Sondek
@es
John Sondek
@nl
John Sondek
@sl
P106
P1153
7004761664
P21
P31
P496
0000-0002-1127-8310