Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor - Test2 - elhamkhani - TriplyDB

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

http://www.wikidata.org/entity/Q27640358

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The role of protein-tyrosine phosphatase 1B in integrin signaling Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway Kinetic and structural analysis of a bacterial protein tyrosine phosphatase-like myo-inositol polyphosphatase Small molecule tools for functional interrogation of protein tyrosine phosphatases A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation.Crystal structure of the Yersinia protein-tyrosine phosphatase YopH complexed with a specific small molecule inhibitor Structural genomics of protein phosphatases Structure of human dual specificity protein phosphatase 23, VHZ, enzyme-substrate/product complex Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes Structure of the Trypanosoma cruzi protein tyrosine phosphatase TcPTP1, a potential therapeutic target for Chagas’ disease The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells.Probing protein-tyrosine phosphatase substrate specificity using a phosphotyrosine-containing phage library.A two stage click-based library of protein tyrosine phosphatase inhibitors Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening Targeting PTPs with small molecule inhibitors in cancer treatment Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B Design and synthesis of nonpeptidic, small molecule inhibitors for the Mycobacterium tuberculosis protein tyrosine phosphatase PtpB Investigating mammalian tyrosine phosphatase inhibitors as potential 'piggyback' leads to target Trypanosoma brucei transmission Targeting protein tyrosine phosphatases for anticancer drug discovery.Enhanced interrogation: emerging strategies for cell signaling inhibition Recent advances in protein tyrosine phosphatase 1B inhibitors.Structure of human dual-specificity phosphatase 7, a potential cancer drug target.Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors Signalling by protein phosphatases and drug development: a systems-centred view.Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking.Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase.Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development.Role of protein phosphatases in genitourinary cancers.Design, synthesis, and evaluation of 2-(arylsulfonyl)oxiranes as cell-permeable covalent inhibitors of protein tyrosine phosphatases.Enzyme-triggered compound release using functionalized antimicrobial peptide derivatives.Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B.Effects of protonation state of Asp181 and position of active site water molecules on the conformation of PTP1B.

P2860

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P2860

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

http://www.wikidata.org/entity/Q27640358

description

2003 nî lūn-bûn

@nan

2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2003年の論文

@ja

2003年論文

@yue

2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

@wuu

name

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@ast

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@en

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@nl

type

label

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@ast

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@en

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@nl

prefLabel

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@ast

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@en

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@nl

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P2860

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P1433

Journal of Biological Chemistry

P1476

Crystal structure of PTP1B complexed with a potent and selective bidentate inhibitor

@en

P2093

Alexander A Fedorov

http://www.w3.org/2001/XMLSchema#string

David S Lawrence

http://www.w3.org/2001/XMLSchema#string

Jin-Peng Sun

http://www.w3.org/2001/XMLSchema#string

Kui Shen

http://www.w3.org/2001/XMLSchema#string

Seung-Yub Lee

http://www.w3.org/2001/XMLSchema#string

Xiao-Ling Guo

http://www.w3.org/2001/XMLSchema#string

Zhong-Yin Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

Identification of protein-tyrosine phosphatase 1B as the major tyrosine phosphatase activity capable of dephosphorylating and activating c-Src in several human breast cancer cell lines

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

PTP1B regulates leptin signal transduction in vivo

Substrate specificity of the protein tyrosine phosphatases

Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

Protein tyrosine phosphatase 1B interacts with and is tyrosine phosphorylated by the epidermal growth factor receptor

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

P304

12406-14

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P31

scholarly article

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2227499

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P356

10.1074/JBC.M212491200

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P407

P433

14

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P478

278

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P50

P577

2003-04-04T00:00:00Z

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P698

12547827

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P921

crystal structure