Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex - Test2 - elhamkhani - TriplyDB

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

http://www.wikidata.org/entity/Q27640372

about

GSK-3β: A Bifunctional Role in Cell Death Pathways Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs Wnt signaling: the good and the bad Axin and GSK3- control Smad3 protein stability and modulate TGF- signaling The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway The many faces and functions of β-catenin p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses Structural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6 beta-catenin destruction complex: insights and questions from a structural perspective The β-catenin destruction complex Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus Frat is dispensable for canonical Wnt signaling in mammals Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions Understanding protein non-folding.Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling.Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion Wingless signalling alters the levels, subcellular distribution and dynamics of Armadillo and E-cadherin in third instar larval wing imaginal discs.Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6.Substrate and docking interactions in serine/threonine protein kinases Axin downregulates TCF-4 transcription via beta-catenin, but not p53, and inhibits the proliferation and invasion of lung cancer cells.A noncatalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity Niclosamide is a potential therapeutic for familial adenomatosis polyposis by disrupting Axin-GSK3 interaction.Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system.Stochastic machines as a colocalization mechanism for scaffold protein function Prediction of the binding mode between GSK3β and a peptide derived from GSKIP using molecular dynamics simulation.Use of molecular modeling, docking, and 3D-QSAR studies for the determination of the binding mode of benzofuran-3-yl-(indol-3-yl)maleimides as GSK-3beta inhibitors Allosteric regulation of glycogen synthase kinase 3β: a theoretical study.CDK5 activator protein p25 preferentially binds and activates GSK3β Intrinsic disorder in scaffold proteins: getting more from less Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice.The Wnt/β-catenin pathway in human fibrotic-like diseases and its eligibility as a therapeutic target.Mining alpha-helix-forming molecular recognition features with cross species sequence alignments.

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P2860

Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex

http://www.wikidata.org/entity/Q27640372

description

2003 nî lūn-bûn

@nan

2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

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2003年论文

@wuu

name

Structural basis for recruitme ...... the axin-APC scaffold complex

@ast

Structural basis for recruitme ...... the axin-APC scaffold complex

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Structural basis for recruitme ...... the axin-APC scaffold complex

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type

label

Structural basis for recruitme ...... the axin-APC scaffold complex

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Structural basis for recruitme ...... the axin-APC scaffold complex

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Structural basis for recruitme ...... the axin-APC scaffold complex

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prefLabel

Structural basis for recruitme ...... the axin-APC scaffold complex

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Structural basis for recruitme ...... the axin-APC scaffold complex

@en

Structural basis for recruitme ...... the axin-APC scaffold complex

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P2860

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P1433

The EMBO Journal

P1476

Structural basis for recruitme ...... the axin-APC scaffold complex

@en

P2093

Elizabeth Fraser

http://www.w3.org/2001/XMLSchema#string

Laurence H Pearl

http://www.w3.org/2001/XMLSchema#string

Maggie Yeo

http://www.w3.org/2001/XMLSchema#string

Rana Dajani

http://www.w3.org/2001/XMLSchema#string

S Mark Roe

http://www.w3.org/2001/XMLSchema#string

Trevor C Dale

http://www.w3.org/2001/XMLSchema#string

Valerie M Good

http://www.w3.org/2001/XMLSchema#string

Vivienne Thompson

http://www.w3.org/2001/XMLSchema#string

P2860

Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2

GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis

Identification of c-MYC as a target of the APC pathway

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition

The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation

P304

494-501

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scholarly article

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2561098

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10.1093/EMBOJ/CDG068

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P407

P433

3

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22

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2003-02-03T00:00:00Z

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10928016

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12554650

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140752

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