p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses
about
Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe MoleculesFluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α KinaseDeveloping advanced X-ray scattering methods combined with crystallography and computationAnacardic acid inhibits the catalytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinasesA comparative study of fragment screening methods on the p38α kinase: new methods, new insights.Polyphony: superposition independent methods for ensemble-based drug discovery.Structural basis of p38α regulation by hematopoietic tyrosine phosphatase.The differential regulation of p38α by the neuronal kinase interaction motif protein tyrosine phosphatases, a detailed molecular studyA Comprehensive Structural Overview of p38α MAPK in Complex with Type I Inhibitors.Computational generation inhibitor-bound conformers of p38 MAP kinase and comparison with experiments.Dynamic profile analysis to characterize dynamics-driven allosteric sites in enzymes.Novel approaches for targeting kinases: allosteric inhibition, allosteric activation and pseudokinases.Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.Scaffold mining of kinase hinge binders in crystal structure database.Structure- and ligand-based drug design of novel p38-alpha MAPK inhibitors in the fight against the Alzheimer's disease.Biosensor-based approach to the identification of protein kinase ligands with dual-site modes of action.
P2860
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P2860
p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@ast
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@en
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@nl
type
label
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@ast
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@en
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@nl
prefLabel
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@ast
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@en
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@nl
P2093
P2860
P3181
P1476
p38α MAP Kinase C-Terminal Dom ...... hic and Computational Analyses
@en
P2093
Arthur J Olson
Davide Moiani
J Jefferson P Perry
John A Tainer
Rodney M Harris
P2860
P3181
P356
10.1016/J.JMB.2009.06.005
P407
P577
2009-08-07T00:00:00Z