Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
about
GSK-3 Inhibitors: Preclinical and Clinical Focus on CNSGSK-3β: A Bifunctional Role in Cell Death PathwaysTrans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangePhosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinasesDirect inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signalingGlycogen synthase kinase 3: more than a namesakeAllosteric activation of the protein kinase PDK1 with low molecular weight compoundsExploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3PAK5 kinase is an inhibitor of MARK/Par-1, which leads to stable microtubules and dynamic actin.Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashionThe C terminus of initiation factor 4E-binding protein 1 contains multiple regulatory features that influence its function and phosphorylationA sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growthNoninvasive molecular imaging of c-Myc activation in living miceThe Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationGSK-3: tricks of the trade for a multi-tasking kinaseNicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotauAdaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1Loss of muscle mass: current developments in cachexia and sarcopenia focused on biomarkers and treatmentStructural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complexAutophosphorylation Activates Dictyostelium Myosin II Heavy Chain Kinase A by Providing a Ligand for an Allosteric Binding Site in the -Kinase DomainStructures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate RecognitionStructural basis of GSK-3 inhibition by N-terminal phosphorylation and by the Wnt receptor LRP6Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growthA noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteinsA-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3betaAxin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathwayFRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylationA critical role for IGF-II in memory consolidation and enhancement.Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative diseaseA New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cellsActivated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivoInhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survivalRole of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathwayProbing sporadic and familial Alzheimer's disease using induced pluripotent stem cellsA dual-kinase mechanism for Wnt co-receptor phosphorylation and activationConformational basis for SH2-Tyr(P)527 binding in Src inactivation.Flexible nets. The roles of intrinsic disorder in protein interaction networks.Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.
P2860
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P2860
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Crystal structure of glycogen ...... specificity and autoinhibition
@ast
Crystal structure of glycogen ...... specificity and autoinhibition
@en
Crystal structure of glycogen ...... specificity and autoinhibition
@nl
type
label
Crystal structure of glycogen ...... specificity and autoinhibition
@ast
Crystal structure of glycogen ...... specificity and autoinhibition
@en
Crystal structure of glycogen ...... specificity and autoinhibition
@nl
prefLabel
Crystal structure of glycogen ...... specificity and autoinhibition
@ast
Crystal structure of glycogen ...... specificity and autoinhibition
@en
Crystal structure of glycogen ...... specificity and autoinhibition
@nl
P2093
P3181
P1433
P1476
Crystal structure of glycogen ...... specificity and autoinhibition
@en
P2093
P304
P3181
P356
10.1016/S0092-8674(01)00374-9
P407
P577
2001-06-15T00:00:00Z