The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
about
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonismDoubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by DeacylcortivazolIdentification of a potent synthetic FXR agonist with an unexpected mode of binding and activationShoot-and-Trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallographyX-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulationPrinciples for modulation of the nuclear receptor superfamilyNuclear receptors as drug targets for metabolic disease.Identification of novel liver X receptor activators by structure-based modelingThe X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design.Evolution of promiscuous nuclear hormone receptors: LXR, FXR, VDR, PXR, and CARLigands of Therapeutic Utility for the Liver X Receptors.Targeted Delivery of LXR Agonist Using a Site-Specific Antibody-Drug ConjugateTranscriptional regulation of the human pregnane-X receptor.Ligand specificity and evolution of liver X receptors.Intrinsic disorder in nuclear hormone receptors.Two- and three-dimensional quantitative structure-activity relationships studies on a series of liver x receptor ligands.Targeting liver X receptors in human health: deadlock or promising trail?Incorporating protein flexibility into docking and structure-based drug design.Targeting liver X receptors in inflammation.A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.Divergent effect of liver X receptor agonists on prostate-specific antigen expression is dependent on androgen receptor in prostate carcinoma cells.The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease.Predicting selective liver X receptor β agonists using multiple machine learning methods.Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulatorsOrphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential.Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain.Synthetic LXR agonists increase LDL in CETP species.Computational studies of LXR molecular interactions reveal an allosteric communication pathway.Dendrogenin A drives LXR to trigger lethal autophagy in cancers.Ouabagenin is a naturally occurring LXR ligand without causing hepatic steatosis as a side effect.Selective modulation of glucocorticoid receptor function toward development of novel anti-inflammation: lessons from a phenyl-pyrazolo-steroid cortivazol.Development of Tetrachlorophthalimides as Liver X Receptor β (LXRβ)-Selective Agonists.Liver X receptors regulate hepatic F4/80 + CD11b+ Kupffer cells/macrophages and innate immune responses in mice.
P2860
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P2860
The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands
description
2003 nî lūn-bûn
@nan
2003 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
The three-dimensional structur ...... undamentally different ligands
@ast
The three-dimensional structur ...... undamentally different ligands
@en
The three-dimensional structur ...... undamentally different ligands
@nl
type
label
The three-dimensional structur ...... undamentally different ligands
@ast
The three-dimensional structur ...... undamentally different ligands
@en
The three-dimensional structur ...... undamentally different ligands
@nl
prefLabel
The three-dimensional structur ...... undamentally different ligands
@ast
The three-dimensional structur ...... undamentally different ligands
@en
The three-dimensional structur ...... undamentally different ligands
@nl
P2093
P2860
P356
P1476
The three-dimensional structur ...... undamentally different ligands
@en
P2093
Anna Wilhelmsson
Harri Ahola
Jan Ljunggren
Mathias Färnegårdh
Mats Carlquist
Sherry Sun
Tomas Bonn
P2860
P304
P356
10.1074/JBC.M304842200
P407
P577
2003-10-03T00:00:00Z