Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol - Test2 - elhamkhani - TriplyDB

Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

http://www.wikidata.org/entity/Q27649439

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Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators Structures and mechanism for the design of highly potent glucocorticoids Collective dynamics differentiates functional divergence in protein evolution Structure of a 13-fold superhelix (almost) determined from first principles.Ultrafast protein structure-based virtual screening with Panther.Comparing pharmacophore models derived from crystal structures and from molecular dynamics simulations Investigation on critical structural motifs of ligands for triggering glucocorticoid receptor nuclear migration through molecular docking simulations.Hormone binding and co-regulator binding to the glucocorticoid receptor are allosterically coupled.The nuclear receptor, Nor-1, markedly increases type II oxidative muscle fibers and resistance to fatigue.Insights on glucocorticoid receptor activity modulation through the binding of rigid steroids.Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.Thiazolidinediones are partial agonists for the glucocorticoid receptor.Structural and functional insights into nuclear receptor signaling.Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors.The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: addressing the "core issue" in the design of estrogen receptor ligands The road less traveled: new views of steroid receptor action from the path of dose-response curves.Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.Structural Analysis on the Pathologic Mutant Glucocorticoid Receptor Ligand-Binding Domains.Alternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration model Modulation of transcription parameters in glucocorticoid receptor-mediated repression.Mutations of glucocorticoid receptor differentially affect AF2 domain activity in a steroid-selective manner to alter the potency and efficacy of gene induction and repression.Evolution of hormone signaling in elasmobranchs by exploitation of promiscuous receptors.Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists.Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands.Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids.Recent advances in the development of novel glucocorticoid receptor modulators.Rational structure-based drug design and optimization in the ligand-binding domain of the glucocorticoid receptor-α.Rational ligand-based virtual screening and structure-activity relationship studies in the ligand-binding domain of the glucocorticoid receptor-α.Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.Modeling studies on the structural determinants for the DAG/phorbol ester binding to C1 domain.Role of pocket flexibility in the modulation of estrogen receptor alpha by key residue arginine 394.

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Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol

http://www.wikidata.org/entity/Q27649439

description

2008 nî lūn-bûn

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2008 թուականի Մարտին հրատարակուած գիտական յօդուած

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2008 թվականի մարտին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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Molecular and Cellular Biology

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Chenghai Zhang

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H Eric Xu

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W David Tolbert

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Yong-Guang Tao

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P2860

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor

Structural plasticity in the oestrogen receptor ligand-binding domain

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1915-23

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4649244

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10.1128/MCB.01541-07

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6

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28

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2008-03-01T00:00:00Z

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5688185

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18160712

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2268401

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