Exploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat Paratope
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Toward chaperone-assisted crystallography: Protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffoldA Dominant Conformational Role for Amino Acid Diversity in Minimalist Protein–Protein InterfacesNanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificusStructural Basis for Exquisite Specificity of Affinity Clamps, Synthetic Binding Proteins Generated through Directed Domain-interface EvolutionAn anti-hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loopA combinatorial histidine scanning library approach to engineer highly pH-dependent protein switchesTeaching an Old Scaffold New Tricks: Monobodies Constructed Using Alternative Surfaces of the FN3 ScaffoldStructural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH DomainsStructural basis of an engineered dual-specific antibody: conformational diversity leads to a hypervariable loop metal-binding siteEngineering of recombinant crystallization chaperonesNeutralization of Clostridium difficile toxin A with single-domain antibodies targeting the cell receptor binding domainThe "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability.Application of protein engineering to enhance crystallizability and improve crystal properties.The importance of being tyrosine: lessons in molecular recognition from minimalist synthetic binding proteins.Generating conformation-specific synthetic antibodies to trap proteins in selected functional statesCritical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis.Toxin-specific antibodies for the treatment of Clostridium difficile: current status and future perspectives.Multivalent anchoring and oriented display of single-domain antibodies on cellulose.Antibody light chain variable domains and their biophysically improved versions for human immunotherapy.Biotechnological applications of recombinant single-domain antibody fragments.Systematic mutation and thermodynamic analysis of central tyrosine pairs in polyspecific NKG2D receptor interactions.The interface between Escherichia coli elongation factor Tu and aminoacyl-tRNA.Unveiling a Drift Resistant Cryptotope within Marburgvirus Nucleoprotein Recognized by Llama Single-Domain Antibodies.The clinical potential of circulating tumor cells; the need to incorporate a modern "immunological cocktail" in the assay.Nanobodies and their potential applications.Mutational analysis of domain antibodies reveals aggregation hotspots within and near the complementarity determining regions.A Modular Receptor Platform To Expand the Sensing Repertoire of Bacteria.The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic FabComputational B-cell epitope identification and production of neutralizing murine antibodies against Atroxlysin-I
P2860
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P2860
Exploring the Capacity of Minimalist Protein Interfaces: Interface Energetics and Affinity Maturation to Picomolar KD of a Single-domain Antibody with a Flat Paratope
description
2007 nî lūn-bûn
@nan
2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@ast
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@en
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@nl
type
label
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@ast
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@en
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@nl
prefLabel
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@ast
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@en
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@nl
P2093
P2860
P1476
Exploring the Capacity of Mini ...... Antibody with a Flat Paratope
@en
P2093
Akiko Koide
Anthony A Kossiakoff
Katrina Margalef
Serdar Uysal
P2860
P304
P356
10.1016/J.JMB.2007.08.027
P407
P577
2007-11-02T00:00:00Z