Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs - Test2 - elhamkhani - TriplyDB

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

http://www.wikidata.org/entity/Q27649382

about

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis Regulation of small GTPases by GEFs, GAPs, and GDIs International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.Function and regulation of the Rho guanine nucleotide exchange factor Trio Recognition of the Activated States of Gα13 by the rgRGS Domain of PDZRhoGEF Structural Determinants of G-protein Subunit Selectivity by Regulator of G-protein Signaling 2 (RGS2)Structure-function study of the N-terminal domain of exocyst subunit Sec3 Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex Identification of Critical Residues in G 13 for Stimulation of p115RhoGEF Activity and the Structure of the G 13-p115RhoGEF Regulator of G Protein Signaling Homology (RH) Domain Complex Structural Basis for Autoinhibition of the Guanine Nucleotide Exchange Factor FARP2 Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex Crystal structure of mouse RhoA:GTPγS complex in a centered lattice A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins Structural determinants involved in the formation and activation of G protein betagamma dimers.The phospholipase C isozymes and their regulation Kalrn plays key roles within and outside of the nervous system Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location Strike a pose: Gαq complexes at the membrane p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.TRPC Channels Mediate a Muscarinic Receptor-Induced Afterdepolarization in Cerebral Cortex.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Activation state-dependent interaction between Gαq subunits and the Fhit tumor suppressor.Association of activated Gαq to the tumor suppressor Fhit is enhanced by phospholipase Cβ Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq Stimulation of α1a adrenergic receptors induces cellular proliferation or antiproliferative hypertrophy dependent solely on agonist concentration High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay Overexpression of GEFT, a Rho family guanine nucleotide exchange factor, predicts poor prognosis in patients with rhabdomyosarcoma.Novel insights into G protein and G protein-coupled receptor signaling in cancer Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6.G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.Kalrn promoter usage and isoform expression respond to chronic cocaine exposure Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling Lysophosphatidic acid-induced RhoA signaling and prolonged macrophage infiltration worsens fibrosis and fatty infiltration following rotator cuff tears.

P2860

Q24294907-9A866B9B-270E-4C10-B938-5E7A35A1E530 Q24304013-C6E72A3D-221C-429D-9817-252589830DA5 Q26825750-09A31FC4-A3BB-4DD0-BF45-265D623C1964 Q26827568-F9A1080A-FB49-4F75-9607-7C635F50608D Q26995249-1550791B-0798-4DBA-9CE7-3DFFF55B3278 Q26995528-BF686045-19D6-4C5C-984C-1166BB278461 Q27652593-5B89B237-898B-4200-B95B-3E654D078EEB Q27655668-79CA1921-E330-4ABF-86AF-0BA06C60D942 Q27659629-67378650-B6BE-4B89-B463-8711FE3286C3 Q27663562-35D0AEF1-DA72-48F0-85ED-0531CCB3B5B2 Q27665290-3CC98F3C-5BD5-454A-873C-624D653CB664 Q27667495-C05E450B-06D7-4BDC-B671-D9A56E3A9449 Q27676119-FF661FA7-0E60-4D16-AC2C-9A4EFEF556B8 Q27676578-6B1D33FB-B26C-4323-864B-70617FD43957 Q27682445-8F65DA3C-0E48-4337-B08D-DC1685615690 Q27687313-82682F92-CD6B-4E87-8103-19AB1D2EBA0D Q27865227-AA7243FC-9083-4EBB-B859-0908814EF18A Q28261474-4A84E4B6-0B82-455B-920C-61FF53BBAE35 Q28513985-5FC9812F-1CD5-4ACC-9216-88FA88B2DD36 Q28592541-B1BE0361-AA08-4D8F-ADDC-54E04ADBE21D Q28673501-1054D343-3A65-4B6A-919F-71C69D07C30E Q30356183-51E24CDC-3E9F-46FE-B289-6DF01DE4C55F Q30424559-3DC8557D-0499-44DC-B855-DFF1D202443E Q30437078-945D9749-82BA-4416-ACA1-CBBB76A82A95 Q30439430-22579AC7-3DD0-458F-8C27-0F3FE99FD122 Q30543570-E24740A7-574A-49FF-A620-465DE2848491 Q30670527-3A95E1CF-3FB5-499B-ACE2-2016D8345C71 Q30828274-AADAEDD0-7A1F-4AB8-9356-319B2E315C1E Q31132937-EFB7DEA3-1D70-42DE-B4E1-566340BFE9C2 Q33406057-68DEA257-724D-42C8-9E42-B40178456E0F Q33583005-3BD60678-15F8-4EFF-B6F4-4715E7348AB6 Q33612895-C935D550-91EF-4D7E-9EF9-D730A83A967C Q33613391-B3691BDE-C445-4838-AD48-64E18454A7D4 Q33658160-F1801A96-07F8-404C-8223-9F2CDA78F23F Q33809957-8013064E-61F3-4282-8ECD-B87CB72E4DBE Q33822971-196235E3-C124-450B-AE8C-414028BC6576 Q33823125-2126B0EE-402F-43F5-B606-8DD63126B40E Q33855025-BC12068D-E5A2-4E23-9536-702F1FF76EE6 Q33870671-F6F74A68-3552-4333-911D-EFB16ECF1B4A Q33887329-82B66F16-F919-4961-AA2A-817BDC748125

P2860

Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs

http://www.wikidata.org/entity/Q27649382

description

2007 nî lūn-bûn

@nan

2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@ast

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@en

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@nl

type

label

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@ast

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@en

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@nl

prefLabel

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@ast

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@en

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@nl

P1433

Q27649382-3CDC4440-0130-4A59-805E-6F8C6E5ED21B

P1476

Q27649382-708DD990-6C23-4E8E-82FF-84C568B4B93F

P2093

Q27649382-144C1B43-E80C-4952-824F-27EECA20000A

Q27649382-172578BE-B4DE-4654-82D7-55572BACE07A

Q27649382-73706DAC-9D9F-4C59-B6DC-547A2558D293

Q27649382-74FB1FDF-E1A3-44EB-B20B-02F2C8A6AE98

Q27649382-89CF1A61-AD55-407F-95B4-35B42E0A8E99

Q27649382-8BCC28F7-7487-4B23-8E9D-7871154FC086

Q27649382-A4ADBEE0-397D-44E0-AACC-B2D49BE0381D

Q27649382-AEEE1F42-23FF-4BC2-ACCC-BA12C96402A0

Q27649382-B514EB98-3471-4B08-B4EB-3194BC4F450D

Q27649382-F5DBC321-864F-42FF-AFBE-AA621AA18E95

P2860

Q27649382-024A56FF-E40F-47EB-ADFD-11EB9D3B89C2

Q27649382-09E2BD8B-7018-48F6-85D1-8A54AB881A23

Q27649382-3C7C271E-BE56-48EE-931C-2E7A17241846

Q27649382-62CC5FC2-D0EA-410F-BF8B-D5EB4EE99942

Q27649382-72C411CA-301B-4B74-9538-FD2D943038F2

Q27649382-7A49FA51-7130-4DEF-945A-F74D1E98E80E

Q27649382-BC093BA0-384A-41AF-AA6E-2CBA08B60728

Q27649382-C5C30F7F-AC58-47F3-8306-0974BB7625D9

Q27649382-D0160856-B966-4B9C-84B6-7362C7D74C34

Q27649382-D102720B-F876-4019-BED6-0E6D8BEA5C3B

P304

Q27649382-3FD66A6A-9820-45DE-86F6-2B7753F338C0

P31

Q27649382-B8E0F684-318D-4F29-B29B-C82A4063D722

P3181

Q27649382-ABCE755B-76A8-4BF2-BDF4-90BA6405331E

P356

Q27649382-1679019B-8DC9-4BA2-92D8-D338F30C1A20

P407

Q27649382-51FAFF17-BA86-4CB0-9EA4-EAE749A961AA

P433

Q27649382-91E8B366-520D-4C7E-B288-F0A26DE59248

P478

Q27649382-4080065F-6318-44C4-A50C-E222ADB61D93

P577

Q27649382-E86E1445-95E5-4101-87A4-3FE6C3565EFD

P5875

Q27649382-C2C1B14A-31A6-4C1C-A703-8348C19AF444

P698

Q27649382-DAD4325B-6EB4-44A4-B17A-54DF92B3D44E

P921

Q27649382-F3F854AC-BE3D-487E-A823-413A5BFA41CF

P3181

P356

SCIENCE.1147554

P1433

P1476

Structure of Galphaq-p63RhoGEF ...... he activation of RhoA by GPCRs

@en

P2093

Aruna Shankaranarayanan

http://www.w3.org/2001/XMLSchema#string

Cassandra Coco

http://www.w3.org/2001/XMLSchema#string

Chris R Evelyn

http://www.w3.org/2001/XMLSchema#string

Christiane Vettel

http://www.w3.org/2001/XMLSchema#string

Doris Baltus

http://www.w3.org/2001/XMLSchema#string

John J G Tesmer

http://www.w3.org/2001/XMLSchema#string

Marc Ridilla

http://www.w3.org/2001/XMLSchema#string

Mark R Nance

http://www.w3.org/2001/XMLSchema#string

Richard R Neubig

http://www.w3.org/2001/XMLSchema#string

Susanne Lutz

http://www.w3.org/2001/XMLSchema#string

P2860

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene

Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

P304

1923-7

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

2590751

http://www.w3.org/2001/XMLSchema#string

P356

10.1126/SCIENCE.1147554

http://www.w3.org/2001/XMLSchema#string

P407

P433

5858

http://www.w3.org/2001/XMLSchema#string

P478

318

http://www.w3.org/2001/XMLSchema#string

P577

2007-12-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5751940

http://www.w3.org/2001/XMLSchema#string

P698

18096806

http://www.w3.org/2001/XMLSchema#string

P921

G protein-coupled receptor